WEKO3
アイテム
{"_buckets": {"deposit": "0a4039ee-bbc7-4c2b-962c-b026d67b922e"}, "_deposit": {"created_by": 3, "id": "5293", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "5293"}, "status": "published"}, "_oai": {"id": "oai:toyama.repo.nii.ac.jp:00005293", "sets": ["648"]}, "author_link": ["159338", "159337", "159335", "159336"], "item_2_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2001-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "153", "bibliographicPageStart": "147", "bibliographicVolumeNumber": "18", "bibliographic_titles": [{"bibliographic_title": "和漢医薬学雑誌 = Journal of traditional medicines"}]}]}, "item_2_description_15": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "We analyzed the free radical reaction in the body in vivo under the conditions of renal failure, using an L-band electron spin resonance apparatus. In rats with adenine-induced renal failure, the attenuation velocity of 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl was lowered in comparison with normal rats, indicating that they were in a state of augmented oxidation. In contrast, the attenuation velocity was higher in rats given Wen-Pi-Tang, showing a shift toward reduction. In the kidney of rats given Wen-Pi-Tang, we also found that a significant decrease in glutathione disulfide (GSSG) level caused an increase in the glutathione/GSSG ratio. In addition, there were significant reductions of increased thiobarbituric acid-reactive substance level and decreased superoxide dismutase and increased glutathione peroxidase activities, suggesting a decreased hydrogen peroxide production, which presumably drove the glutathione redox cycle toward reduction. The results of the present study suggest the possibility that Wen-Pi-Tang exerts an antioxidant effect through regulation of the redox cycle.\n L-バンドESR(生体計測用ESR)装置を用い,腎不全における生体内フリーラジカル反応を解析した。アデニン誘発腎不全ラット腎では,正常ラットより3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxylの減衰速度が遅延し,酸化亢進状態にあった。これに対し,温脾湯投与群では減衰速度が速やかとなり,還元方向に変換していた。一方,温脾湯投与群の腎臓では増加したグルタチオンジスルフィドレベルの有意な低下からグルタチオン/グルタチオンジスルフィド比の上昇が認められ,また増加したチオバルビツール酸反応物質レベル,低下したスーパーオキシドジスムターゼと上昇したグルタチオンレダクターゼ活性の有意な低下から,過酸化水素の産生低下が示唆され,グルタチオン酸化還元サイクルを還元方向に作動しているものと考えられた。以上より,温脾湯は酸化還元サイクル調節を介して抗酸化作用を発揮する可能性が示唆された。", "subitem_description_type": "Abstract"}]}, "item_2_description_40": {"attribute_name": "資源タイプ(DSpace)", "attribute_value_mlt": [{"subitem_description": "Article", "subitem_description_type": "Other"}]}, "item_2_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "159338", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "横澤, 隆子"}]}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "和漢医薬学会"}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "rights: 本文データは和漢医薬学会の許諾に基づき複製したものである"}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN10486121", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_8": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "13406302", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yokozawa, Takako"}], "nameIdentifiers": [{"nameIdentifier": "159335", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "RHYU, DongYoung"}], "nameIdentifiers": [{"nameIdentifier": "159336", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Owada, Shigeru"}], "nameIdentifiers": [{"nameIdentifier": "159337", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-02-17"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "20010402.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "20010402.pdf", "url": "https://toyama.repo.nii.ac.jp/record/5293/files/20010402.pdf"}, "version_id": "90b0124d-dff2-46db-a4ac-cf43c299be26"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "in vivo ESR", "subitem_subject_scheme": "Other"}, {"subitem_subject": "free radical", "subitem_subject_scheme": "Other"}, {"subitem_subject": "glutathione redox cycle", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Wen-Pi-Tang", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Increase of radical in rats with adenine-induced renal failure is suppressed by Wen-Pi-Tang", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Increase of radical in rats with adenine-induced renal failure is suppressed by Wen-Pi-Tang"}]}, "item_type_id": "2", "owner": "3", "path": ["648"], "permalink_uri": "http://hdl.handle.net/10110/1937", "pubdate": {"attribute_name": "公開日", "attribute_value": "2008-01-24"}, "publish_date": "2008-01-24", "publish_status": "0", "recid": "5293", "relation": {}, "relation_version_is_last": true, "title": ["Increase of radical in rats with adenine-induced renal failure is suppressed by Wen-Pi-Tang"], "weko_shared_id": -1}
Increase of radical in rats with adenine-induced renal failure is suppressed by Wen-Pi-Tang
http://hdl.handle.net/10110/1937
http://hdl.handle.net/10110/193766bc8bea-813d-443e-b80b-472ccdaca71f
名前 / ファイル | ライセンス | アクション |
---|---|---|
![]() |
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2008-01-24 | |||||
タイトル | ||||||
タイトル | Increase of radical in rats with adenine-induced renal failure is suppressed by Wen-Pi-Tang | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | in vivo ESR | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | free radical | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glutathione redox cycle | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Wen-Pi-Tang | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yokozawa, Takako
× Yokozawa, Takako× RHYU, DongYoung× Owada, Shigeru |
|||||
著者別名 | ||||||
姓名 | 横澤, 隆子 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We analyzed the free radical reaction in the body in vivo under the conditions of renal failure, using an L-band electron spin resonance apparatus. In rats with adenine-induced renal failure, the attenuation velocity of 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl was lowered in comparison with normal rats, indicating that they were in a state of augmented oxidation. In contrast, the attenuation velocity was higher in rats given Wen-Pi-Tang, showing a shift toward reduction. In the kidney of rats given Wen-Pi-Tang, we also found that a significant decrease in glutathione disulfide (GSSG) level caused an increase in the glutathione/GSSG ratio. In addition, there were significant reductions of increased thiobarbituric acid-reactive substance level and decreased superoxide dismutase and increased glutathione peroxidase activities, suggesting a decreased hydrogen peroxide production, which presumably drove the glutathione redox cycle toward reduction. The results of the present study suggest the possibility that Wen-Pi-Tang exerts an antioxidant effect through regulation of the redox cycle. L-バンドESR(生体計測用ESR)装置を用い,腎不全における生体内フリーラジカル反応を解析した。アデニン誘発腎不全ラット腎では,正常ラットより3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxylの減衰速度が遅延し,酸化亢進状態にあった。これに対し,温脾湯投与群では減衰速度が速やかとなり,還元方向に変換していた。一方,温脾湯投与群の腎臓では増加したグルタチオンジスルフィドレベルの有意な低下からグルタチオン/グルタチオンジスルフィド比の上昇が認められ,また増加したチオバルビツール酸反応物質レベル,低下したスーパーオキシドジスムターゼと上昇したグルタチオンレダクターゼ活性の有意な低下から,過酸化水素の産生低下が示唆され,グルタチオン酸化還元サイクルを還元方向に作動しているものと考えられた。以上より,温脾湯は酸化還元サイクル調節を介して抗酸化作用を発揮する可能性が示唆された。 |
|||||
書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 18, 号 4, p. 147-153, 発行日 2001-08 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13406302 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10486121 | |||||
権利 | ||||||
権利情報 | rights: 本文データは和漢医薬学会の許諾に基づき複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |