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A case of rheumatoid arthritis with a decrease in the serum concentration of soluble CD23 by traditional herbal medicine
http://hdl.handle.net/10110/1968
http://hdl.handle.net/10110/196841dafc6f-facc-4316-8569-0f640ce6f4bb
名前 / ファイル | ライセンス | アクション |
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19990503.pdf (807.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-01-25 | |||||
タイトル | ||||||
タイトル | A case of rheumatoid arthritis with a decrease in the serum concentration of soluble CD23 by traditional herbal medicine | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Kampo treatment | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Immunomodulation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | clinical course | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | case report | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kogure, Toshiaki
× Kogure, Toshiaki× Niizawa, Atsushi× fujinaga, Hiroshi× Sakai, Shinya× HAI, LeXuan× Shimada, Yutaka× Terasawa, Katsutoshi |
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著者別名 | ||||||
姓名 | 小暮, 敏明 | |||||
著者別名 | ||||||
姓名 | 嶋田, 豊 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Traditional herbal (Kampo) medicine for the treatment of rheumatoid arthritis (RA) has not been evaluated for changes in immune status during its use, although several anti-inflammatory effects have been studied in vitro. In this case report, we describe a 32-year-old Japanese female with RA who was effectively treated with the Kampo medicine, Hochu-ekki to (Bu-Zhong-Yi-Qi-Tang, 補中益気湯) . This treatment decreased the serum concentration of soluble CD23 (sCD23) and RA activity, in addition to tumor necrosis factor-α. These findings suggest that the therapeutic action of herbal medicine might be attributable to suppression of B cell activation. 和漢薬治療は慢性関節リウマチ(RA)に対して極めて有用な治療法であるが,その作用機序に関しては,In Vitroによる生薬の抗炎症効果は解析されているものの,In Vivoでの免疫学的な評価はいまだ未着手な部分が多い。われわれは補中益気湯などが有効であったRAの一例を経験した。この患者は,RAの疾患活動性の低下に加えて血清中可溶性CD23(sCD23)が低下し,さらに,血清TNF-α濃度も,漸次低下していた。このことからRAの治療において和漢薬は単に抗炎症効果を有するだけでなくImmunomodulatorとして作用している可能性が示唆された。その一部としてRA患者でのB細胞の活性化を抑制している可能性がある。 |
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書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 16, 号 5/6, p. 190-195, 発行日 1999-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13406302 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10486121 | |||||
権利 | ||||||
権利情報 | rights: 本文データは和漢医薬学会の許諾に基づき複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |