{"created":"2023-07-25T09:04:23.030122+00:00","id":2216,"links":{},"metadata":{"_buckets":{"deposit":"1683c95e-b589-49f6-b62d-9b2335f766b8"},"_deposit":{"created_by":3,"id":"2216","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2216"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00002216","sets":["439:440:441:442"]},"author_link":["132438","132435","132434","132436","5921","132441","132440","8047"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5/6","bibliographicPageEnd":"195","bibliographicPageStart":"190","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"和漢医薬学雑誌 = Journal of traditional medicines"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Traditional herbal (Kampo) medicine for the treatment of rheumatoid arthritis (RA) has not been evaluated for changes in immune status during its use, although several anti-inflammatory effects have been studied in vitro. In this case report, we describe a 32-year-old Japanese female with RA who was effectively treated with the Kampo medicine, Hochu-ekki to (Bu-Zhong-Yi-Qi-Tang, 補中益気湯) . This treatment decreased the serum concentration of soluble CD23 (sCD23) and RA activity, in addition to tumor necrosis factor-α. These findings suggest that the therapeutic action of herbal medicine might be attributable to suppression of B cell activation.\n 和漢薬治療は慢性関節リウマチ(RA)に対して極めて有用な治療法であるが,その作用機序に関しては,In Vitroによる生薬の抗炎症効果は解析されているものの,In Vivoでの免疫学的な評価はいまだ未着手な部分が多い。われわれは補中益気湯などが有効であったRAの一例を経験した。この患者は,RAの疾患活動性の低下に加えて血清中可溶性CD23(sCD23)が低下し,さらに,血清TNF-α濃度も,漸次低下していた。このことからRAの治療において和漢薬は単に抗炎症効果を有するだけでなくImmunomodulatorとして作用している可能性が示唆された。その一部としてRA患者でのB細胞の活性化を抑制している可能性がある。","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"132441","nameIdentifierScheme":"WEKO"}],"names":[{"name":"小暮, 敏明"}]},{"nameIdentifiers":[{"nameIdentifier":"5921","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000080251891","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000080251891"},{"nameIdentifier":"80251891","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000080251891"}],"names":[{"name":"嶋田, 豊"}]}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"和漢医薬学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"rights: 本文データは和漢医薬学会の許諾に基づき複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10486121","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13406302","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kogure, Toshiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Niizawa, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"fujinaga, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakai, Shinya"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"HAI, LeXuan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimada, Yutaka"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Terasawa, Katsutoshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-15"}],"displaytype":"detail","filename":"19990503.pdf","filesize":[{"value":"807.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"19990503.pdf","url":"https://toyama.repo.nii.ac.jp/record/2216/files/19990503.pdf"},"version_id":"faaf8905-86af-4812-b504-57f04778eb84"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Kampo treatment","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunomodulation","subitem_subject_scheme":"Other"},{"subitem_subject":"clinical course","subitem_subject_scheme":"Other"},{"subitem_subject":"case report","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A case of rheumatoid arthritis with a decrease in the serum concentration of soluble CD23 by traditional herbal medicine","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A case of rheumatoid arthritis with a decrease in the serum concentration of soluble CD23 by traditional herbal medicine"}]},"item_type_id":"2","owner":"3","path":["442"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-25"},"publish_date":"2008-01-25","publish_status":"0","recid":"2216","relation_version_is_last":true,"title":["A case of rheumatoid arthritis with a decrease in the serum concentration of soluble CD23 by traditional herbal medicine"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T11:37:18.839462+00:00"}