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Systems consolidation requires postlearning activation of NMDA receptors in the medial prefrontal cortex in trace eyeblink conditioning.
http://hdl.handle.net/10110/00018198
http://hdl.handle.net/10110/0001819806f53e61-fe69-40d0-8848-fab07d24f641
名前 / ファイル | ライセンス | アクション |
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JNeurosci_26_19_5049to5058_Kawahara (336.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-02-22 | |||||
タイトル | ||||||
タイトル | Systems consolidation requires postlearning activation of NMDA receptors in the medial prefrontal cortex in trace eyeblink conditioning. | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Systems consolidation requires postlearning activation of NMDA receptors in the medial prefrontal cortex in trace eyeblink conditioning. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Animals | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Association Learning | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Conditioning, Eyelid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Frontal Lobe | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Male | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rats | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rats, Wistar | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Receptors, N-Methyl-D-Aspartate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Retention (Psychology) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Animals | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Association Learning | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Conditioning, Eyelid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Frontal Lobe | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Male | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rats | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rats, Wistar | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Receptors, N-Methyl-D-Aspartate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Retention (Psychology) | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Takehara-Nishiuchi, Kaori
× Takehara-Nishiuchi, Kaori× Nakao, Kazuhito× Kawahara, Shigenori× Matsuki, Norio× Kirino, Yutaka |
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その他(別言語等)のタイトル | ||||||
その他のタイトル | Systems consolidation requires postlearning activation of NMDA receptors in the medial prefrontal cortex in trace eyeblink conditioning. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The importance of the hippocampus in declarative memory is limited to recently acquired memory, and remotely acquired memory is believed to be stored somewhere in the neocortex. However, it remains unknown how the memory network is reorganized from a hippocampus-dependent form into a neocortex-dependent one. We reported previously that the medial prefrontal cortex (mPFC) is important for this neocortex-dependent remote memory in rat trace eyeblink conditioning. Here, we investigate the involvement of NMDA receptors in the mPFC in this reorganization and determine the time window of their contribution using chronic infusion of an antagonist into the mPFC, specifically during the postlearning consolidation period. The rats with blockade of the mPFC NMDA receptors during the first 1 or 2 weeks after learning showed a marked impairment in memory retention measured 6 weeks after learning, but relearned normally with subsequent conditioning. In contrast, the same treatment had no effect if it was performed during the third to fourth weeks or during the first day just after learning. The specificity of NMDA receptor blockade was confirmed by the reduced long-term potentiation in the hippocampal-prefrontal pathway in these rats. These results suggest that successful establishment of remotely acquired memory requires activation of NMDA receptors in the mPFC during at least the initial week of the postlearning period. Such NMDA receptor-dependent processes may mediate the maturation of neocortical networks that underlies permanent memory storage and serve as a way to reorganize memory circuitry to the neocortex-dependent form. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Journal of neuroscience : the official journal of the Society for Neuroscience 26(19), 5049-5058.(2006) | |||||
書誌情報 |
The Journal of neuroscience : the official journal of the Society for Neuroscience en : The Journal of neuroscience : the official journal of the Society for Neuroscience 巻 26, 号 19, p. 5049-5058, 発行日 2006-05-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1529-2401 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 16687496 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1523/JNEUROSCI.4381-05.2006 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
出版者 | ||||||
出版者 | The American Physiological Society | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |