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Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation
http://hdl.handle.net/10110/00018136
http://hdl.handle.net/10110/00018136c641bd2a-912c-4d74-bcd8-d8c6a6cbfede
名前 / ファイル | ライセンス | アクション |
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CancerScience_106(7)_867to874_Takahashi (2.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-02-08 | |||||
タイトル | ||||||
タイトル | Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Breast cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | imaging | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | inflammation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tissue microenvironment | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Takahashi, Kei
× Takahashi, Kei× Nagai, Nao× Ogura, Keisuke× Tsuneyama, Koichi× Saiki, Ikuo× Irimura, Tatsuro× Hayakawa, Yoshihiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although the importance of the host tissue microenvironment in cancer progression and metastasis has been established, the spatiotemporal process establishing a cancer metastasis-prone tissue microenvironment remains unknown. In this study, we aim to understand the immunological character of a metastasis-prone microenvironment in a murine 4T1 breast tumor model, by using the activation of nuclear factor-jb (NF-jB) in cancer cells as a sensor of inflammatory status and by monitoring its activity by bioluminescence imaging. By using a 4T1 breast cancer cell line stably expressing an NF-jB ⁄ Luc2 reporter gene (4T1 NF-jB cells), we observed significantly increased bioluminescence approximately 7 days after metastasis-prone orthotopic mammary fat-pad inoculation but not ectopic s.c. inoculation of 4T1 NF-jB cells. Such in vivo NF-jB activation within the fat-pad 4T1 tumor was diminished in immune-deficient SCID or nude mice, or T celldepleted mice, suggesting the requirement of host T cell-mediated immune responses. Given the fat-pad 4T1 tumor expressed higher inflammatory mediators in a T cell-dependent mechanism compared to the s.c. tumor, our results imply the importance of the surrounding tissue microenvironment for inflaming tumors by collaborating with T cells to instigate metastatic spread of 4T1 breast cancer cells. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cancer Science, 2015 Jul; 106(7): 867-74 | |||||
書誌情報 |
Cancer Science 巻 106, 号 7, p. 867-874, 発行日 2015-07 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1349-7006 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.1111/cas.12685 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | Wiley | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |