{"created":"2023-07-25T09:15:42.453544+00:00","id":15670,"links":{},"metadata":{"_buckets":{"deposit":"ef9c29fe-ef26-4d4d-b1e4-2dc93016fcf9"},"_deposit":{"created_by":17,"id":"15670","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"15670"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00015670","sets":["646:647:648"]},"author_link":["167715","167716","167714","6558","47801","167717","167719"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"874","bibliographicPageStart":"867","bibliographicVolumeNumber":"106","bibliographic_titles":[{"bibliographic_title":"Cancer Science"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although the importance of the host tissue microenvironment in cancer progression and metastasis has been established, the spatiotemporal process establishing a cancer metastasis-prone tissue microenvironment remains unknown. In this study, we aim to understand the immunological character of a metastasis-prone microenvironment in a murine 4T1 breast tumor model, by using the activation of nuclear factor-jb (NF-jB) in cancer cells as a sensor of inflammatory status and by monitoring its activity by bioluminescence imaging. By using a 4T1 breast cancer cell line stably expressing an NF-jB ⁄ Luc2 reporter gene (4T1 NF-jB cells), we observed significantly increased bioluminescence approximately 7 days after metastasis-prone orthotopic mammary fat-pad inoculation but not ectopic s.c. inoculation of 4T1 NF-jB cells. Such in vivo NF-jB activation within the fat-pad 4T1 tumor was diminished in immune-deficient SCID or nude mice, or T celldepleted mice, suggesting the requirement of host T cell-mediated immune responses. Given the fat-pad 4T1 tumor expressed higher inflammatory mediators in a T cell-dependent mechanism compared to the s.c. tumor, our results imply the importance of the surrounding tissue microenvironment for inflaming tumors by collaborating with T cells to instigate metastatic spread of 4T1 breast cancer cells.","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Cancer Science, 2015 Jul; 106(7): 867-74","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1111/cas.12685","subitem_relation_type_select":"DOI"}}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1349-7006","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takahashi, Kei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagai, Nao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogura, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuneyama, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saiki, Ikuo"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Irimura, Tatsuro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayakawa, Yoshihiro"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-08"}],"displaytype":"detail","filename":"CancerScience_106(7)_867to874_Takahashi.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"CancerScience_106(7)_867to874_Takahashi","url":"https://toyama.repo.nii.ac.jp/record/15670/files/CancerScience_106(7)_867to874_Takahashi.pdf"},"version_id":"8c194622-8e84-4a76-a40d-26990b00ed33"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Breast cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"imaging","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammation","subitem_subject_scheme":"Other"},{"subitem_subject":"T cell","subitem_subject_scheme":"Other"},{"subitem_subject":"tissue microenvironment","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation"}]},"item_type_id":"2","owner":"17","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-08"},"publish_date":"2018-02-08","publish_status":"0","recid":"15670","relation_version_is_last":true,"title":["Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation"],"weko_creator_id":"17","weko_shared_id":17},"updated":"2023-11-06T04:44:36.496509+00:00"}