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Developing of anti-HIV agents from natural resources(Chemical & Pharmacological study)
http://hdl.handle.net/10110/2319
http://hdl.handle.net/10110/2319de68de61-5860-42a0-ac90-df2ffec8d537
名前 / ファイル | ライセンス | アクション |
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wakan05-suppl116.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-02-14 | |||||
タイトル | ||||||
タイトル | Developing of anti-HIV agents from natural resources(Chemical & Pharmacological study) | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | anti-HIV agent | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | reverse transcriptase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | integrase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | phorbol ester | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
MESELHY, MeselhyRagab
× MESELHY, MeselhyRagab× EL, MEKKAWY Sahar× Ma, Chaomei× Nakamura, Norio× TEWTRAKUL, Supinya× Hattori, Masao |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Most drugs clinically used to suppress replication of HIV, the virus that causes AIDS, are nucleosides and their analogs, but their use is limited due to their severe toxicity, emerging drug resistance and cost. These challenges prompt the search for new anti-HIV-1 agents that are affordable for resource-poor countries and have fewer side effects. As an approach, traditional medicines from different places of the world were evaluated with a panel of in vitro bioassays [designed to monitor inhibition of HIV-1-induced cytopathic effect (CPE), and HIV essential enzymes; reverse transcriptase (RT), protease (PR), and integrase (IN)], and active leads were then isolated and identified. In this review, structurally diverse compounds that have potent anti-HIV activity were classified to CPE inhibitors (phorbol diterpenes), RT inhibitors (caffeic acid derivatives and polyphenols), PR-inhibitors (derivatives of oleanane, ursane and lupane type triterpenes). Other compounds included are IN inhibitors. Structural modification of the active compounds and conjugation with synthesized anti-HIV agents were carried out, which, hopefully, could help for developing novel and effective anti-HIV agents. | |||||
書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 22, 号 suppl., p. 116-128, 発行日 2005 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18801447 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12035198 | |||||
権利 | ||||||
権利情報 | rights: 本文データは和漢医薬学会の許諾に基づきCiNiiから複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |