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79(P06) 新規ピペリドン型キラルビルディングブロックの創製とその天然物合成への応用(ポスター発表の部)
http://hdl.handle.net/10110/00018236
http://hdl.handle.net/10110/00018236bdfae522-01c4-4a26-a070-3ab776724a2d
名前 / ファイル | ライセンス | アクション |
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SympoChemNaturalProducts_41_469to474_Toyooka (415.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-03-01 | |||||
タイトル | ||||||
タイトル | 79(P06) 新規ピペリドン型キラルビルディングブロックの創製とその天然物合成への応用(ポスター発表の部) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 79(P06) Synthesis and Its Application to Natural Products Synthesis of New Piperidone Type of Chiral Building Block | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
豊岡, 尚樹
× 豊岡, 尚樹× 奥村, 麻衣子× 四位, 靖仁× 吉田, 泰子× 百瀬, 雄章× 高畑, 廣紀× 根本, 英雄 |
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著者別名 | ||||||
姓名 | Toyooka, Naoki | |||||
著者別名 | ||||||
姓名 | Okumura, Maiko | |||||
著者別名 | ||||||
姓名 | Yotsui, Yasuhito | |||||
著者別名 | ||||||
姓名 | Yoshida, Yasuko | |||||
著者別名 | ||||||
姓名 | Momose, Takefumi | |||||
著者別名 | ||||||
姓名 | Takahata, Hiroki | |||||
著者別名 | ||||||
姓名 | Nemoto, Hideo | |||||
その他(別言語等)のタイトル | ||||||
その他のタイトル | 79(P06) Synthesis and Its Application to Natural Products Synthesis of New Piperidone Type of Chiral Building Block | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We have achieved the synthesis of both enantiomers of the new piperidone type of chiral building block (1) by using bakers' yeast reduction of corresponding β-keto ester or lipase-mediated kinetic resolution of (±)-1 in optically pure state. Its application to the natural products synthesis also has been demonstrated. Thus, the new and flexible route to the diastereodivergent synthesis of the α,α'-disubstituted 3-piperidinol alkaloids was established, and the chiral synthesis of (+)-prosafrinine, (-)-iso-6-cassine, (-)-prosophylline, and (-)-prosopinine has been achieved. As another application to the synthesis of the natural products, we accomplished the first enantioselective total synthesis of the marine alkaloids clavepictine A, B, pictamine, and lepadin B, using an intramolecular Michael type of ring closure reaction to give the 4,6-cis-substituted quinolizidine ring system (3) or an intramolecular aldol type of cyclization to give the 4a,8a-cis-octahydroquinolinone ring core (4) as the key step, respectively, and the absolute stereochemistry of these marine alkaloids was determined by the present chiral syntheses. | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 天然有機化合物討論会講演要旨集 41, 469-474.(1999) | |||||
書誌情報 |
天然有機化合物討論会講演要旨集 en : Symposium on the Chemistry of Natural Products, symposium papers 巻 41, p. 469-474, 発行日 1999-09-01 |
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書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00154136 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.24496/tennenyuki.41.0_469 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
論文ID(NAID) | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 110006681874 | |||||
出版者 | ||||||
出版者 | 天然有機化合物討論会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |