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Organ selectivity of Juzen-taiho-to and Ninjin-yoei-to in the expression of anti-metastatic efficacy
http://hdl.handle.net/10110/1916
http://hdl.handle.net/10110/1916923bbe0c-9b0b-4ca8-8591-50eaed316554
名前 / ファイル | ライセンス | アクション |
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20020303.pdf (921.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-01-23 | |||||
タイトル | ||||||
タイトル | Organ selectivity of Juzen-taiho-to and Ninjin-yoei-to in the expression of anti-metastatic efficacy | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Juzen-taiho-to | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ninjin-yoei-to | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Metastasis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Colon carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Organ selectivity | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Matsuo, Mitsuhiro
× Matsuo, Mitsuhiro× Tani, Tadato× Saiki, Ikuo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 本研究では,マウス結腸癌Colon26-L5細胞の門脈内移入により形成される肝転移および同細胞の尾静脈内移入により形成される肺転移に対する,十全大補湯および人参養栄湯の経口投与による抑制効果を検討した。十全大補湯は肝転移に対して有意に抑制したが,肺転移には抑制効果を示さなかった。これに対して,人参養栄湯は逆の効果,すなわち肝転移には効果を示さなかったが,肺転移に対して有意な抑制を示した。このように,同一の癌細胞と同系のマウスの転移病態モデルを用いて,二つの方剤の臓器選択的な転移抑制効果が観察された。このような効果発現の差異の解釈は,13世紀に確立されたtheory of Jingand Lun(引経報使)の考えに,部分的に通ずるものがあると思われる。 We investigated the inhibitory effect of oral administration of Juzen-taiho-to and Ninjin-yoei-to on liver metastasis caused by intraportal vein injection of colon 26-L5 cells and lung metastasis by intravenous injection of same tumor cells. Juzen-taiho-to significantly inhibited liver metastasis but not lung metastasis. In contrast, Ninjin-yoei-to was effective at inhibiting lung metastasis but not liver metastasis. In the experimental liver and lung metastases model using same tumor in syngeneic mice system, oral administration of both formulations showed a differential pattern with organ selectivity for the expression of anti-metastatic effects. These results suggest that the different expression of the anti-metastatic effects of both Kampo medicines on tumor metastasis are partly based on the medicinal guides according to the theory of Jing and Lun (Inkei-hoshi) formed in the 13th century. |
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書誌情報 |
和漢医薬学雑誌 = Journal of traditional medicines 巻 19, 号 3, p. 93-97, 発行日 2002-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13406302 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10486121 | |||||
権利 | ||||||
権利情報 | rights: 本文データは和漢医薬学会の許諾に基づき複製したものである | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 和漢医薬学会 | |||||
資源タイプ(DSpace) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Article |