{"created":"2023-07-25T09:06:59.660609+00:00","id":5280,"links":{},"metadata":{"_buckets":{"deposit":"df6e312a-a13e-41f8-bd8e-34a0609ce5a4"},"_deposit":{"created_by":3,"id":"5280","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5280"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00005280","sets":["646:647:648"]},"author_link":["159252","159251","6558"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"97","bibliographicPageStart":"93","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"和漢医薬学雑誌 = Journal of traditional medicines"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では,マウス結腸癌Colon26-L5細胞の門脈内移入により形成される肝転移および同細胞の尾静脈内移入により形成される肺転移に対する,十全大補湯および人参養栄湯の経口投与による抑制効果を検討した。十全大補湯は肝転移に対して有意に抑制したが,肺転移には抑制効果を示さなかった。これに対して,人参養栄湯は逆の効果,すなわち肝転移には効果を示さなかったが,肺転移に対して有意な抑制を示した。このように,同一の癌細胞と同系のマウスの転移病態モデルを用いて,二つの方剤の臓器選択的な転移抑制効果が観察された。このような効果発現の差異の解釈は,13世紀に確立されたtheory of Jingand Lun(引経報使)の考えに,部分的に通ずるものがあると思われる。\n We investigated the inhibitory effect of oral administration of Juzen-taiho-to and Ninjin-yoei-to on liver metastasis caused by intraportal vein injection of colon 26-L5 cells and lung metastasis by intravenous injection of same tumor cells. Juzen-taiho-to significantly inhibited liver metastasis but not lung metastasis. In contrast, Ninjin-yoei-to was effective at inhibiting lung metastasis but not liver metastasis. In the experimental liver and lung metastases model using same tumor in syngeneic mice system, oral administration of both formulations showed a differential pattern with organ selectivity for the expression of anti-metastatic effects. These results suggest that the different expression of the anti-metastatic effects of both Kampo medicines on tumor metastasis are partly based on the medicinal guides according to the theory of Jing and Lun (Inkei-hoshi) formed in the 13th century.","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"和漢医薬学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"rights: 本文データは和漢医薬学会の許諾に基づき複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10486121","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13406302","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsuo, Mitsuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tani, Tadato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saiki, Ikuo"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"20020303.pdf","filesize":[{"value":"921.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20020303.pdf","url":"https://toyama.repo.nii.ac.jp/record/5280/files/20020303.pdf"},"version_id":"252ff026-37bb-4be2-829e-244c6716c829"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Juzen-taiho-to","subitem_subject_scheme":"Other"},{"subitem_subject":"Ninjin-yoei-to","subitem_subject_scheme":"Other"},{"subitem_subject":"Metastasis","subitem_subject_scheme":"Other"},{"subitem_subject":"Colon carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"Organ selectivity","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Organ selectivity of Juzen-taiho-to and Ninjin-yoei-to in the expression of anti-metastatic efficacy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Organ selectivity of Juzen-taiho-to and Ninjin-yoei-to in the expression of anti-metastatic efficacy"}]},"item_type_id":"2","owner":"3","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-23"},"publish_date":"2008-01-23","publish_status":"0","recid":"5280","relation_version_is_last":true,"title":["Organ selectivity of Juzen-taiho-to and Ninjin-yoei-to in the expression of anti-metastatic efficacy"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-11-06T04:44:22.478765+00:00"}