{"created":"2023-07-25T09:07:03.003398+00:00","id":5342,"links":{},"metadata":{"_buckets":{"deposit":"480bedf8-9fb2-44a5-94c1-631a685e18bf"},"_deposit":{"created_by":3,"id":"5342","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5342"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00005342","sets":["646:647:648"]},"author_link":["8141","159603","7991","159612","159610","159601","159600","159607","17894","159605","159608"],"item_2_alternative_title_19":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Quantitative analysis of Chinese crude drug, \"Shigao (Gypsum)\" extract by atomic absorption spectrounetry"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"28","bibliographicPageStart":"24","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"和漢医薬学雑誌 = Journal of traditional medicines"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_31":{"attribute_name":"スポンサー","attribute_value_mlt":[{"subitem_description":"Toyama Medical and Pharmaceutical University : 21st Century COE Program","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Shigao (石膏)\" is one of the Chinese mineral drugs, derived from calcium sulfate dihydrate (Gypsum, CaSO_4 ' 2H_20), which has been used as antipyretic for heat in the lung with high fever and dire thirst. In general, Japanese Kampo or Chinese medical doctors have made allowance for the amount of gypsum according to symptom complex of patients when they make decoctions of some formulations such as Byakko-ka-ninjin-to. However, the dissolution rate of gypsum with increasing amount was not clear. We extracted gypsum with hot water to measure the concentration of calcium using the atomic absorption spectrometry. The results showed that the calcium concentration was approximately 200 ppm when 10 g of block form of gypsum was used for one hour extraction and the dissolution rate was increased depending on the amount of gypsum and the length of extraction time. However, in the case of the powder form of gypsum, the calcium concentration was approximately 550 ppm for 15 min extraction and the dissolution rate was almost constant, independent of the amount of gypsum and extraction time. Thus, the block form of gypsum is better to use in order to be able to control the dissolution rate. Moreover, according to X-ray diffraction method and fluorescent X-ray analysis, the crystal structures and the contents of inorganic compounds were not changed before and after extraction, suggesting that the block form of gypsum has the possibility to be used several times.\n 「石膏」は『神農本草経』の上品に「石膏味辛微寒主中風寒熱心下逆気驚喘口乾舌焦不能息腹中堅痛除邪鬼産乳金瘡」と記載されている漢薬で, 古来, 清熱, 止渇, 鎮咳薬として白虎加人参湯, 麻杏甘石湯, 釣藤散などの処方に配合される。石膏の基源にっいては日本及び中国で, 天然の含水硫酸カルシウム(CaSO_4・2H_20)であると規定されている。漢方医学において石膏は, 大黄, 附子と共にしばしば\"さじ加減\"して用いられる代表的な生薬の一つで, 漢方処方では通常5～10gを配合すると記載されているが, 実際の臨床では, 患者の熱感や口渇の程度を指標として使用量を増減することが多い。塩谷らは加減一陰煎加亀板膠に, 新たに石膏を5～20g加えることにより, 成人型アトピー性皮膚炎において著効が得られたことを報告している。 一方, これまで石膏は水に対して難溶であることから, その薬理効果が疑問視されてきた。石膏の水への溶解性に関してはこれまで, 硫酸イオンを指標とした研究5)や, ICP発光分析による無機成分の溶出挙動に関する研究が報告されている。","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"8141","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002393623","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002393623"},{"nameIdentifier":"30313620","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000030313620"}],"names":[{"name":"Fushimi, Hirotoshi"}]},{"nameIdentifiers":[{"nameIdentifier":"159607","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Oda, Shinobu"}]},{"nameIdentifiers":[{"nameIdentifier":"159608","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Itoh, Takashi"}]},{"nameIdentifiers":[{"nameIdentifier":"7991","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10272907","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000010272907"}],"names":[{"name":"Shibahara, Naotoshi"}]},{"nameIdentifiers":[{"nameIdentifier":"159610","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kita, Toshiaki"}]},{"nameIdentifiers":[{"nameIdentifier":"17894","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050225570","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000050225570"},{"nameIdentifier":"50225570","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000050225570"}],"names":[{"name":"Komatsu, Katsuko"}]},{"nameIdentifiers":[{"nameIdentifier":"159612","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Terasawa, Katsutoshi"}]}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"和漢医薬学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"rights: 本文データは和漢医薬学会の許諾に基づきCiNiiから複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12035198","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"18801447","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伏見, 裕利"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"織田, しのぶ"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊藤, 隆"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"柴原, 直利"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"喜多, 敏明"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小松, かつ子"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"寺澤, 捷年"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"wakan05-24.pdf","filesize":[{"value":"687.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"wakan05-24.pdf","url":"https://toyama.repo.nii.ac.jp/record/5342/files/wakan05-24.pdf"},"version_id":"deb0c993-3e08-480c-a6dd-a89a1c996db7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"gypsum","subitem_subject_scheme":"Other"},{"subitem_subject":"atomic absorption spectrometry","subitem_subject_scheme":"Other"},{"subitem_subject":"calcium","subitem_subject_scheme":"Other"},{"subitem_subject":"X-ray diffraction method","subitem_subject_scheme":"Other"},{"subitem_subject":"fluorescent X-ray analysis","subitem_subject_scheme":"Other"},{"subitem_subject":"scanning electron microscopy","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"原子吸光光度法を用いた漢薬「石膏」の溶出量に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"原子吸光光度法を用いた漢薬「石膏」の溶出量に関する研究"}]},"item_type_id":"2","owner":"3","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-02-14"},"publish_date":"2008-02-14","publish_status":"0","recid":"5342","relation_version_is_last":true,"title":["原子吸光光度法を用いた漢薬「石膏」の溶出量に関する研究"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-11-06T04:42:38.130377+00:00"}