{"created":"2023-07-25T09:07:02.486508+00:00","id":5330,"links":{},"metadata":{"_buckets":{"deposit":"7ba0702b-1fce-4cc3-a009-67d1f93a4e5d"},"_deposit":{"created_by":3,"id":"5330","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5330"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00005330","sets":["646:647:648"]},"author_link":["159535","159537","159536","159534"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"136","bibliographicPageStart":"128","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"和漢医薬学雑誌 = Journal of traditional medicines"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_31":{"attribute_name":"スポンサー","attribute_value_mlt":[{"subitem_description":"21st COE Program, University of Toyama","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A single subcutaneous injection of indomethacin (INDO) in mice induced enteropathy characterized as ulceration in small intestine, which was associated with the elevation of fecal hemoglobin (Hb) content and the decrease in Hb and total protein concentration in blood. Oral administration of Scutellariae Radix (SR) (500 mg/kg) enhanced fecal Hb excretion but did not affect the decrease in blood Hb and total protein concentration in INDO-treated mice. In contrast, administration of two SR-containing kampo formulas, Orengedokuto (OGT) and San'oshashinto (SST) at 1100 mg/kg, which contained nearly the same amounts of baicalin as SR extracts at 500 mg/kg, markedly suppressed INDO-induced intestinal bleeding and blood loss. Plasma INDO concentration was not changed by the administration of SR, OGT or SST. The present study suggests that OGT and SST are useful for limiting complications such as intestinal bleeding and blood loss associated with INDO-induced enteropathy. However, possible harmful effects of other SR-containing kampo formulas on INDO-induced enteropathy remain to be investigated.\n インドメタシン(INDO)の単投与により,糞中へのヘモグロビン(Hb)排泄と血中のヘモグロビンと総タンパク濃度の低下を伴う腸疾患症状がマウスにおいて誘発された。マウスにあらかじめオウゴンエキス(SR,500mg/kg, 2回/日)を投与しところ,糞中へのHb排泄量が有意に増加したが,血中のHbおよび総タンパク濃度には変化しなかった。これに対して,SRを含有する黄連解毒湯(OGT)および三黄瀉心湯(SST)を1100mg/kgにて投与したところ,INDOによる糞中へのHbの排泄や血中Hbおよび総タンパク濃度の低下は顕著に抑制された。SR, OGTおよびSSTの投与は,血中のINDO濃度の変化には影響しなかった。本研究の結果は,INDO誘発性腸疾患に伴う消化管出血や血液損失の制御において,OGTやSSTが有用である可能性を示唆する。しかしながら,これら以外のSR含有漢方方剤のINDO誘発性腸疾患に対する有害性の可能性についても検討されるべきである。","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"159537","nameIdentifierScheme":"WEKO"}],"names":[{"name":"渡辺, 志朗"}]}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"和漢医薬学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"rights: 本文データは和漢医薬学会の許諾に基づきCiNiiから複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12035198","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"18801447","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamada, Yasuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Ryo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Shiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"wakan07-128.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"wakan07-128.pdf","url":"https://toyama.repo.nii.ac.jp/record/5330/files/wakan07-128.pdf"},"version_id":"75f65e4a-c684-4641-9e48-ea837d51063c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"NSAIDs","subitem_subject_scheme":"Other"},{"subitem_subject":"small intestine","subitem_subject_scheme":"Other"},{"subitem_subject":"hemoglobin","subitem_subject_scheme":"Other"},{"subitem_subject":"bleeding","subitem_subject_scheme":"Other"},{"subitem_subject":"blood loss","subitem_subject_scheme":"Other"},{"subitem_subject":"baicalin","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Scutellariae Radix enhances but Scutellariae Radix-containing Kampo formulas, Orengedokuto and San'oshashinto, prevent intestinal bleeding associated with indomethacin-induced enteropathy in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Scutellariae Radix enhances but Scutellariae Radix-containing Kampo formulas, Orengedokuto and San'oshashinto, prevent intestinal bleeding associated with indomethacin-induced enteropathy in mice"}]},"item_type_id":"2","owner":"3","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-28"},"publish_date":"2008-01-28","publish_status":"0","recid":"5330","relation_version_is_last":true,"title":["Scutellariae Radix enhances but Scutellariae Radix-containing Kampo formulas, Orengedokuto and San'oshashinto, prevent intestinal bleeding associated with indomethacin-induced enteropathy in mice"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-11-06T04:44:33.038813+00:00"}