{"created":"2023-07-25T09:07:02.146996+00:00","id":5322,"links":{},"metadata":{"_buckets":{"deposit":"0ca5905d-7f2f-4a56-a754-77e985957e27"},"_deposit":{"created_by":3,"id":"5322","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5322"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00005322","sets":["646:647:648"]},"author_link":["159497","17930","159494","159496","159499","159498","159495"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"168","bibliographicPageStart":"163","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"和漢医薬学雑誌 = Journal of traditional medicines"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effect of paeoniflorin on learning impairment of operant brightness discrimination performance　was investigated in rats with unilateral nucleus basalis magnocellularis（NBM）lesion. The animals　with unilateral NBM lesion exhibited a significant acquisition impairment of brightness discrimination task during the early phase of a training period（1-5days after starting the training session). When　administered daily during a training period，paeoniflorin significantly improved the learning impairment　of unilateral NBM-lesioned rats at 0.01 but not 0.1mg／kg／day（p.o.）. Tacrine （0.3mg／kg／day，p.o.）， a　cholinesterase inhibitor，also significantly ameliorated the learning deficit. These results suggest that　paeoniflorin improves the impairment of non-spatial learning performance caused by cholinergic　dysfunction in rats and that it may have a beneficial effect on senile dementia.","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"和漢医薬学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"rights: 本文データは和漢医薬学会の許諾に基づき複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10486121","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13406302","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsumoto, Kinzo"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Akazawa, Ko-hei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murakami, Yukihisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimizu, Mineo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ichiki, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Maruno, Masao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Hiroshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"19970301.pdf","filesize":[{"value":"900.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"19970301.pdf","url":"https://toyama.repo.nii.ac.jp/record/5322/files/19970301.pdf"},"version_id":"d814b26f-c792-40af-9285-81edce068b9e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"paeoniflorin unilateral nucleus basalis magnocellularis lesion","subitem_subject_scheme":"Other"},{"subitem_subject":"brightness discrimination task","subitem_subject_scheme":"Other"},{"subitem_subject":"rat","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Paeoniflorin ameliorates acquisition impairment of a simple operant discrimination performance caused by unilateral nucleus basalis magnocellularis lesion in rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Paeoniflorin ameliorates acquisition impairment of a simple operant discrimination performance caused by unilateral nucleus basalis magnocellularis lesion in rats"}]},"item_type_id":"2","owner":"3","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-25"},"publish_date":"2008-01-25","publish_status":"0","recid":"5322","relation_version_is_last":true,"title":["Paeoniflorin ameliorates acquisition impairment of a simple operant discrimination performance caused by unilateral nucleus basalis magnocellularis lesion in rats"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-11-06T04:44:31.296909+00:00"}