@article{oai:toyama.repo.nii.ac.jp:00005322,
 author = {Matsumoto, Kinzo and Akazawa, Ko-hei and Murakami, Yukihisa and Shimizu, Mineo and Ichiki, Hiroyuki and Maruno, Masao and Watanabe, Hiroshi},
 issue = {3},
 journal = {和漢医薬学雑誌 = Journal of traditional medicines},
 month = {Jan},
 note = {application/pdf, The effect of paeoniflorin on learning impairment of operant brightness discrimination performance　was investigated in rats with unilateral nucleus basalis magnocellularis（NBM）lesion. The animals　with unilateral NBM lesion exhibited a significant acquisition impairment of brightness discrimination task during the early phase of a training period（1-5days after starting the training session). When　administered daily during a training period，paeoniflorin significantly improved the learning impairment　of unilateral NBM-lesioned rats at 0.01 but not 0.1mg／kg／day（p.o.）. Tacrine （0.3mg／kg／day，p.o.）， a　cholinesterase inhibitor，also significantly ameliorated the learning deficit. These results suggest that　paeoniflorin improves the impairment of non-spatial learning performance caused by cholinergic　dysfunction in rats and that it may have a beneficial effect on senile dementia., Article},
 pages = {163--168},
 title = {Paeoniflorin ameliorates acquisition impairment of a simple operant discrimination performance caused by unilateral nucleus basalis magnocellularis lesion in rats},
 volume = {14},
 year = {1997}
}