@article{oai:toyama.repo.nii.ac.jp:00005320, author = {Yokozawa, Takako and LIU, ZhongWu and CHEN, CuiPing}, issue = {4}, journal = {和漢医薬学雑誌 = Journal of traditional medicines}, month = {Jan}, note = {application/pdf, The effects of Carthami Flos,Rhei Rhizoma and Astragali Radix extract,which have been proved to ameliorate renal failure in rats with glycerol-induced renal failure,were examined in cell culture under three different culture conditions.Rhei Rhizoma extract showed the most potent effect among the three crude drugs under any of the routine,hypoxia-reoxygenation and cisplatin exposure conditions employed,suggesting that its favorable effect on proximal tubule function is due to suppression of lipid peroxidation via free radicals.In contrast,this anti-cytotoxic activity was low in Astragali Radix extract,and almost nil in Carthami Flos extract.These results indicate that Rhei Rhizoma,Astragali Radix and Carthami Flos exert their actions on different sites in the kidney., Article}, pages = {202--207}, title = {Evaluation of Oriental medicines using a cultured renal epithelial cell line, LLC-PK_1 : Effects of Carthami Flos, Rhei Rhizoma and Astragali Radix}, volume = {15}, year = {1998} }