{"created":"2023-07-25T09:07:01.889170+00:00","id":5316,"links":{},"metadata":{"_buckets":{"deposit":"9978003a-b20e-41f3-a585-b11849fa61ba"},"_deposit":{"created_by":3,"id":"5316","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5316"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00005316","sets":["646:647:648"]},"author_link":["159462","159465","159461","159464","159463"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5/6","bibliographicPageEnd":"200","bibliographicPageStart":"196","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"和漢医薬学雑誌 = Journal of traditional medicines"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Anti-Helicobacter pylori (HP) activities were examined, by disc method, on three total alkaloid fractions and fourteen steroidal alkaloids obtained from three Veratrum plants ( V. manckii, V. nigrum var. ussuriense and V. patulum) , which are used as a name of \"Li-lu (藜蘆)\" to treat aphasia arising from apoplexy, wind type dysentery, jaundice, headache, scabies, chronic malaria, etc. Among them, verapatulin (12) and veratramine (13) revealed anti-HP activities, and the disc-minimum inhibitory concentration (disk-MIC) value (10 μg/ml) of 12 against two standard HP strains, NCTC11637 and NCTC11916, was higher than that of a clinically used antibiotic, erythromycin (≦0.013 μg/ml) , but was comparable to those of penicillin G (3.1 μg/ml and 1.6 μg/ml, respectively).\n 漢薬\"藜蘆\"として用いられている3種のヴェラトラム属植物(V.maackii, V.nigrum var.ussuriense and V.patulum)から得た総アルカロイドフラクション3種及ぴステロイドアルカロイド14種について,抗ヘリコバクター・ピロリ活性をディスク法で測定した。調べたステロイドアルカロイドの中で,ヴェラパツリン(12)及ぴヴェラトラミン(13)が抗ヘリコバクター・ピロリ活性を示した。ヴェラパツリン(12)のヘリコバグター・ピロリ標準株2種(NCTC11637及ぴNCTC11916)に対するdisk MIC値は10μg/mlであり,臨床で用いられる抗生物質のエリスロマイシン(≦0.013μg/ml)よりは弱いが,ペニシリンG(各標準株に対して3.1μg/ml,1.6μg/ml)と同程度であった。","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"159465","nameIdentifierScheme":"WEKO"}],"names":[{"name":"門田, 重利"}]}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"和漢医薬学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"rights: 本文データは和漢医薬学会の許諾に基づき複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10486121","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13406302","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tezuka, Yasuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"ZHAO, Weijie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishii, Eiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kadota, Shigetoshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"19990504.pdf","filesize":[{"value":"640.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"19990504.pdf","url":"https://toyama.repo.nii.ac.jp/record/5316/files/19990504.pdf"},"version_id":"73423970-75e1-4590-9bae-84da0a177b33"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Helicobacter pylori","subitem_subject_scheme":"Other"},{"subitem_subject":"steroidal alkaloid","subitem_subject_scheme":"Other"},{"subitem_subject":"ri-ro（li-lu, 藜蘆）","subitem_subject_scheme":"Other"},{"subitem_subject":"verapatulin","subitem_subject_scheme":"Other"},{"subitem_subject":"antibacterial agent","subitem_subject_scheme":"Other"},{"subitem_subject":"Veratrum patulum","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Anti-Helicobacter pylori activity of steroidal alkaloids obtained from three Veratrum plants","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Anti-Helicobacter pylori activity of steroidal alkaloids obtained from three Veratrum plants"}]},"item_type_id":"2","owner":"3","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-25"},"publish_date":"2008-01-25","publish_status":"0","recid":"5316","relation_version_is_last":true,"title":["Anti-Helicobacter pylori activity of steroidal alkaloids obtained from three Veratrum plants"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-11-06T04:44:30.041056+00:00"}