@article{oai:toyama.repo.nii.ac.jp:00005316,
 author = {Tezuka, Yasuhiro and ZHAO, Weijie and Ishii, Eiji and Kadota, Shigetoshi},
 issue = {5/6},
 journal = {和漢医薬学雑誌 = Journal of traditional medicines},
 month = {Dec},
 note = {application/pdf, Anti-Helicobacter pylori (HP) activities were examined, by disc method, on three total alkaloid fractions and fourteen steroidal alkaloids obtained from three Veratrum plants ( V. manckii, V. nigrum var. ussuriense and V. patulum) , which are used as a name of "Li-lu (藜蘆)" to treat aphasia arising from apoplexy, wind type dysentery, jaundice, headache, scabies, chronic malaria, etc. Among them, verapatulin (12) and veratramine (13) revealed anti-HP activities, and the disc-minimum inhibitory concentration (disk-MIC) value (10 μg/ml) of 12 against two standard HP strains, NCTC11637 and NCTC11916, was higher than that of a clinically used antibiotic, erythromycin (≦0.013 μg/ml) , but was comparable to those of penicillin G (3.1 μg/ml and 1.6 μg/ml, respectively).
 漢薬"藜蘆"として用いられている3種のヴェラトラム属植物(V.maackii, V.nigrum var.ussuriense and V.patulum)から得た総アルカロイドフラクション3種及ぴステロイドアルカロイド14種について,抗ヘリコバクター・ピロリ活性をディスク法で測定した。調べたステロイドアルカロイドの中で,ヴェラパツリン(12)及ぴヴェラトラミン(13)が抗ヘリコバクター・ピロリ活性を示した。ヴェラパツリン(12)のヘリコバグター・ピロリ標準株2種(NCTC11637及ぴNCTC11916)に対するdisk MIC値は10μg/mlであり,臨床で用いられる抗生物質のエリスロマイシン(≦0.013μg/ml)よりは弱いが,ペニシリンG(各標準株に対して3.1μg/ml,1.6μg/ml)と同程度であった。, Article},
 pages = {196--200},
 title = {Anti-Helicobacter pylori activity of steroidal alkaloids obtained from three Veratrum plants},
 volume = {16},
 year = {1999}
}