{"created":"2023-07-25T09:07:00.846213+00:00","id":5300,"links":{},"metadata":{"_buckets":{"deposit":"f84cfa39-a1a7-485d-8a04-934a8e92ad4f"},"_deposit":{"created_by":3,"id":"5300","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5300"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00005300","sets":["646:647:648"]},"author_link":["159377"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"47","bibliographicPageStart":"39","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"和漢医薬学雑誌 = Journal of traditional medicines"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Wakan-yaku (Japanese-Chinese traditional medicines) are natural products and its constituents and/or activities depend on several factors, such as species, timing of collection, producing area, individual, etc. Thus, in order to use a homogeneous Wakan-yaku (Japanese-Chinese traditional medicines), it is necessary to use it with an evaluation on the equality of the constituents and/or activities of them, and the effective method for detecting the qualitative and/or quantitative change of the constituents and/or activities is required. However, almost all methods currently in use are based on the comparison of some representative constituents or activities and thus are not suitable for Wakan-yaku (Japanese-Chinese traditional medicines) which usually have many constituents and activities. On the other hand, application of gas chromatography-mass spectrometry (GC-MS) and liquid chromato-graphy-mass spectrometry (LC-MS) has recently been attempted, due to the possibility of measuring many compounds at once. This review deals with the LC-MS method, applicable to several types of compounds, by taking the case of our comparative study on the seventeen Salvia plants.\n 和漢薬は天然物であり,その成分や活性は種,採集時期,産地,個体等,種々の要因に依存する。そのため,均質な和漢薬を用いるには,その成分や活性の同等性を評価した上で用いる必要があり,成分含量や活性の変化を検出する有効な方法が必要とされている。しかし従来法の多くは,少数の代表的成分や活性の比較であり,多成分,多活性を有する和漢薬に適した方法ではなかった。一方,多成分の同時測定が可能なことから,ガスクロマトグラフィ連結質量分析計(GC-MS)や液体クロマトグラフィ連結質量分析計(LC-MS)の応用が近年試みられている。本稿では,種々のタイプの化合物に適応容易なLC-MS法について,我々が行なった漢薬\"丹参\"の基源植物間の比較を例として述べた。","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"和漢医薬学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"rights: 本文データは和漢医薬学会の許諾に基づき複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10486121","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13406302","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tezuka, Yasuhiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"20010201.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20010201.pdf","url":"https://toyama.repo.nii.ac.jp/record/5300/files/20010201.pdf"},"version_id":"6f0423a5-5c40-4519-8c7e-c72192f504df"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Liquid chromatography-mass spectrometry (LC-MS)","subitem_subject_scheme":"Other"},{"subitem_subject":"equality-evaluation","subitem_subject_scheme":"Other"},{"subitem_subject":"qualityevaluation","subitem_subject_scheme":"Other"},{"subitem_subject":"Tan-jin (Dan-shen, 丹参)","subitem_subject_scheme":"Other"},{"subitem_subject":"genus Salvia","subitem_subject_scheme":"Other"},{"subitem_subject":"aldose reductase inhibition","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Equality-evaluation of Wakan-yaku (Japanese-Chinese traditional medicines) with liquid chromatography-mass spectrometry (LC-MS) : comparison of constituents of original plants for Chinese traditional medicine \"Dan-shen (Tan-j in)\"","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Equality-evaluation of Wakan-yaku (Japanese-Chinese traditional medicines) with liquid chromatography-mass spectrometry (LC-MS) : comparison of constituents of original plants for Chinese traditional medicine \"Dan-shen (Tan-j in)\""}]},"item_type_id":"2","owner":"3","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-24"},"publish_date":"2008-01-24","publish_status":"0","recid":"5300","relation_version_is_last":true,"title":["Equality-evaluation of Wakan-yaku (Japanese-Chinese traditional medicines) with liquid chromatography-mass spectrometry (LC-MS) : comparison of constituents of original plants for Chinese traditional medicine \"Dan-shen (Tan-j in)\""],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-11-06T04:44:26.654365+00:00"}