{"created":"2023-07-25T09:07:00.713354+00:00","id":5298,"links":{},"metadata":{"_buckets":{"deposit":"de8a6119-c3f1-4755-9326-d8df5b22112c"},"_deposit":{"created_by":3,"id":"5298","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5298"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00005298","sets":["646:647:648"]},"author_link":["159372","159370","159371"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"112","bibliographicPageStart":"107","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"和漢医薬学雑誌 = Journal of traditional medicines"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Advanced glycation endproducts (AGEs) are largely involved in the pathogenesis of diabetic nephropathy. It is apparent that inhibition of AGEs formation is important in preventing the occurrence and progression of nephropathy. Therefore, to seek possible AGEs inhibitors in Oriental medicines, we began our investigation with an in vitro evaluation system. Among the 12 Oriental medical prescriptions examined, Ompi-to inhibited AGEs formation to the greatest extent, followed by Tokaku-joki-to and Keishi-bukuryo-gan and Daio-botampi-to in that order. Among the 21 component galenicals examined, Rhei Rhizoma, Cinnamomi Cortex, Moutan Cortex and Paeoniae Radix all had a potent inhibitory action, indicating that Rhei Rhizoma, vascular system disturbance -eliminating drugs and tannin-containing crude drugs can all inhibit the formation of AGEs. These Oriental prescriptions and component galenicals proved to have more potent inhibitory activity than the positive control aminoguanidine.\n  advanced glycation endproducts(AGE)は糖尿病性腎症の成因に大きく関与しており,AGE生成の抑制が腎症発症・進展防止に重要であることが知られている。このことから,本研究ではAGE阻害薬の可能性を和漢薬に求め,in vitroの評価系で検討した。使用した漢方方剤12種類のうち,最もAGE生成を抑制した漢方方剤は温脾湯で,次いで桃核承気湯,桂枝茯苓丸,大黄牡丹皮湯の順であった。実験に供した21種類の構成生薬では大黄,桂皮,牡丹皮,芍薬に強い抑制作用を認め,大黄剤,駆〓血剤ならびにタンニン生薬がAGEの生成を抑制しているものと考えられた。またこれらは陽性対照物質のアミノグアニジンより強い活性を示した。","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"和漢医薬学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"rights: 本文データは和漢医薬学会の許諾に基づき複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10486121","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13406302　","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yokozawa, Takako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakagawa, Takako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Terasawa, Katsutoshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"20010302.pdf","filesize":[{"value":"889.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20010302.pdf","url":"https://toyama.repo.nii.ac.jp/record/5298/files/20010302.pdf"},"version_id":"9bbf07b3-b785-4cc3-bfed-40350324ec91"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"advanced glycation endproducts","subitem_subject_scheme":"Other"},{"subitem_subject":"diabetic nephropathy","subitem_subject_scheme":"Other"},{"subitem_subject":"Ompi-to","subitem_subject_scheme":"Other"},{"subitem_subject":"Rhei Rhizoma","subitem_subject_scheme":"Other"},{"subitem_subject":"aminoguanidine","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Oriental medicines on the production of advanced glycation endproducts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Oriental medicines on the production of advanced glycation endproducts"}]},"item_type_id":"2","owner":"3","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-24"},"publish_date":"2008-01-24","publish_status":"0","recid":"5298","relation_version_is_last":true,"title":["Effects of Oriental medicines on the production of advanced glycation endproducts"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-11-06T04:44:26.251567+00:00"}