@article{oai:toyama.repo.nii.ac.jp:00005291,
 author = {Nakagawa, Takako and Yokozawa, Takako and Terasawa, Katsutoshi},
 issue = {4},
 journal = {和漢医薬学雑誌 = Journal of traditional medicines},
 month = {Aug},
 note = {application/pdf, The effects of four Kampo medicines, Ompi-to, Hachimi-jio-gan, Keishi-bukuryo-gan and Sairei-to, were investigated in rats with diabetic nephropathy induced by subtotal nephrectomy and injection of streptozotocin. To evaluate their effects on the glycation reaction, excessive activity of the polyol pathway and oxidative stress (abnormal bio-chemical processes induced by persistent hyperglycemia), we determined levels of the major endproducts of these processes: advanced glycation endproducts (AGEs) and sorbitol in the kidney and lipid peroxidation in the serum. These three processes were all enhanced in rats with untreated diabetic nephropathy. Oral administration of all four medicines significantly lowered AGEs levels. The renal sorbitol concentration was significantly lowered in the Hachimi-jio-gan-, Sairei-to- and Keishi-bukuryo-gan-treated groups compared with the untreated control group. Serum lipid peroxidation was significantly lowered in the Keishi-bukuryo-gan, Ompi-to and Sairei-to groups, while creatinine clearance and urinary protein excretion (parameters of renal function) were ameliorated by Keishi-bukuryo-gan and Hachimi-jio-gan, respectively, indicating retardation of the progression of diabetic nephropathy. These results suggest the potential therapeutic usefulness of Kampo medicines as a treatment for diabetic nephropathy. It is believed that their actions may occur through different mechanisms.
 漢方方剤(温脾湯,八味地黄丸,桂枝茯苓丸,柴苓湯)の糖尿病性腎症に及ぼす影響を,モデルラットを用い検討した。慢性的な高血糖状態では糖化反応,ポリオール経路,酸化ストレスの亢進をひき起こすが,これらの指標の腎組織中のadvanced glycation endproducts(AGEs)とソルビトール,血中脂質過酸化量は,いずれも糖尿病性腎症ラットで有意に増加していた。これに対し,4種類の漢方方剤を投与した群では,いずれの場合も腎組織中のAGEsレベルが有意に低下していた。しかしソルビトール含量は八味地黄丸,柴苓湯,桂枝茯苓丸投与群で,血中脂質過酸化量は桂枝茯苓丸,温脾湯,柴苓湯投与群で有意に低下していた。また腎機能パラメーターのクレアチニンクリアランスと尿蛋白排泄量は桂枝茯苓丸,八味地黄丸投与群で有意に改善していた。このことから,4種類の漢方方剤はそれぞれ異なった作用機序で,糖尿病性腎症の進展を抑制している可能性が示唆された。, Article},
 pages = {161--168},
 title = {A study of Kampo medicines in a diabetic nephropathy model},
 volume = {18},
 year = {2001}
}