{"created":"2023-07-25T09:06:59.859615+00:00","id":5283,"links":{},"metadata":{"_buckets":{"deposit":"bd9ca11e-42ed-45f8-8047-ececdcf0330d"},"_deposit":{"created_by":3,"id":"5283","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5283"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00005283","sets":["646:647:648"]},"author_link":["159277","159272","159270","159279","17930","159274","159268","159269","159271","159278","159264","159276","159266","159265","159273"],"item_2_alternative_title_19":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Protective effect of Choto-san, Chotoko and its alkaloids on experimental vascular dementia in mice : Elucidation using Morris water maze test"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"36","bibliographicPageStart":"28","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"和漢医薬学雑誌 = Journal of traditional medicines"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It has been reported that Choto-san has an effect on treatment of vascular dementia in clinical tests. In the present study, we investigated the effect of Choto-san and its main constituent Chotoko (Uncariae uncis cum ramulus) on the spatial cognitive impairment induced by transient cerebral ischemia in mice in the Morris water maze performance. The spatial cognitive deficiency caused by transient cerebral ischemia in mice exhibited an increase of escape latency and a reduction of swimming time in the platform quadrant. Choto-san (750-6000 mg/kg, p.o.) and Chotoko (75-600 mg/kg, p.o.) administered one hour before the operation shortened the escape latency and increased the swimming time in the platform quadrant, showing a protective effect on the impairment induced by transient cerebral ischemia. Furthermore, we also studied the efficacy of alkaloid fraction, indole alkaloid (geissoschizine methylether) and oxindole alkaloid (rhynchophylline) of Chotoko. The alkaloid fraction (10 mg/kg, p.o.) of Chotoko and rhynchophylline (10 mg/kg, p.o) significantly improved the spatial cognitive impairment induced by transient cerebral ischemia in the Morris water maze, while the protective effect of geissoschizine methylether was weak. These results suggested that Choto-san and Chotoko have a protective effect on transient cerebral ischemia-induced spatial cognitive impairment. The beneficial effect of Chotoko is partly attributed to the oxindole alkaloid rhynchophylline.","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"159272","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ZHANG, Shaohui"}]},{"nameIdentifiers":[{"nameIdentifier":"159273","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Murakami, Yukihisa"}]},{"nameIdentifiers":[{"nameIdentifier":"159274","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tohda, Michihisa"}]},{"nameIdentifiers":[{"nameIdentifier":"17930","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000010114654","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000010114654"},{"nameIdentifier":"10114654","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000010114654"}],"names":[{"name":"Matsumoto, Kinzo"}]},{"nameIdentifiers":[{"nameIdentifier":"159276","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Sakakibara, Iwao"}]},{"nameIdentifiers":[{"nameIdentifier":"159277","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takayama, Hiromitsu"}]},{"nameIdentifiers":[{"nameIdentifier":"159278","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Aimi, Norio"}]},{"nameIdentifiers":[{"nameIdentifier":"159279","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Watanabe, Hiroshi"}]}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"和漢医薬学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"rights: 本文データは和漢医薬学会の許諾に基づき複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10486121","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13406302","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"張, 紹輝"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"村上, 孝寿"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"東田, 道久"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松本, 欣三"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"榊原, 巌"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高山, 廣光"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"相見, 則郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"渡辺, 裕司"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"20020105.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20020105.pdf","url":"https://toyama.repo.nii.ac.jp/record/5283/files/20020105.pdf"},"version_id":"68d54801-714b-4e21-b51f-d58fceef48f6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Choto-san","subitem_subject_scheme":"Other"},{"subitem_subject":"Chotoko","subitem_subject_scheme":"Other"},{"subitem_subject":"Aqueous Extract","subitem_subject_scheme":"Other"},{"subitem_subject":"Alkaloid fraction","subitem_subject_scheme":"Other"},{"subitem_subject":"Geissoschizine methylether","subitem_subject_scheme":"Other"},{"subitem_subject":"Rhynchophylline","subitem_subject_scheme":"Other"},{"subitem_subject":"Transient cerebral ischemia","subitem_subject_scheme":"Other"},{"subitem_subject":"Spatial cognitive impairment","subitem_subject_scheme":"Other"},{"subitem_subject":"Protective effect","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"釣藤散，釣藤鈎及びそのアルカロイド成分の脳虚血予防作用 : マウス水迷路学習行動を指標として","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"釣藤散，釣藤鈎及びそのアルカロイド成分の脳虚血予防作用 : マウス水迷路学習行動を指標として"}]},"item_type_id":"2","owner":"3","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-24"},"publish_date":"2008-01-24","publish_status":"0","recid":"5283","relation_version_is_last":true,"title":["釣藤散，釣藤鈎及びそのアルカロイド成分の脳虚血予防作用 : マウス水迷路学習行動を指標として"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-11-06T04:44:23.070005+00:00"}