{"created":"2023-07-25T09:06:59.135546+00:00","id":5272,"links":{},"metadata":{"_buckets":{"deposit":"1185f632-0265-48d2-8dd5-e4fd0b9c73b5"},"_deposit":{"created_by":3,"id":"5272","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5272"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00005272","sets":["646:647:648"]},"author_link":["159198","159196","159199","159200","159197"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"61","bibliographicPageStart":"57","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"和漢医薬学雑誌 = Journal of traditional medicines"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aemotoxylon campechanumの血糖降下作用をSTZ誘発糖尿病ラットを用いて検討したところ,水エキスが空腹時血糖を有意かつ用量依存的に低下させた。そこで,水エキスをメタノール可溶性フラクション及び水溶性フラクションに分画したところ,メタノール可溶性フラクションがより強い作用を示し,100mg/kgの腹腔内投与で空腹時血糖値を37%低下させた。また,水エキス200mg/kg及びメタノール可溶部100mg/kgは空腹時血糖値を35.1%低下させた陽性コントロールとして用いたtolbutamide(100mg/kg)とbuformin(1mg/kg)の混合物よりも強いものであった。最後に,この活性フラクションの分離を行ない,グアイアン型セスキテルペン5種及びクマリン誘導体1種を単離・同定した。\n Hypoglycemic activity of Aemotoxylon campechanum was examined in STZ-induced diabetic rats. The water extract of A. campechanum lowered fasting blood glucose level of STZ-induced diabetic rats significantly and dosedependently. The water extract further divided into MeOH and H_2O-soluble fractions. The MeOH-soluble fraction showed the strongest hypoglycemic effect, which lowered fasting blood glucose level by 37% at a dose of 100 mg/kg (i. p.). The water extract and the MeOH-soluble fraction were found to be more effective in lowering the blood glucose level of diabetic rats than the mixtures of tolbutamide (200 mg/kg) and buformin (1 mg/kg) used as positive control, which lowered blood glucose level by 35.1%. The active fraction led to isolation of five guainane-type sesquiterpenes and a coumarin derivative.","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"159200","nameIdentifierScheme":"WEKO"}],"names":[{"name":"門田, 重利"}]}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"和漢医薬学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"rights: 本文データは和漢医薬学会の許諾に基づき複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10486121","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13406302","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"BANSKOTA, ArjunH."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Li, Jianping"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tezuka, Yasuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kadota, Shigetoshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"20030203.pdf","filesize":[{"value":"674.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20030203.pdf","url":"https://toyama.repo.nii.ac.jp/record/5272/files/20030203.pdf"},"version_id":"e5bfc88c-8948-4955-a454-02e9d2dfc4d9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Aematoxylon campechanum","subitem_subject_scheme":"Other"},{"subitem_subject":"hypoglycemic effect","subitem_subject_scheme":"Other"},{"subitem_subject":"streptozotocin","subitem_subject_scheme":"Other"},{"subitem_subject":"guainane-type sesquiterpene","subitem_subject_scheme":"Other"},{"subitem_subject":"coumarin","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Hypoglycemic effect of Aemotoxylon campechanum on streptozotocin (STZ)-induced diabetic rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hypoglycemic effect of Aemotoxylon campechanum on streptozotocin (STZ)-induced diabetic rats"}]},"item_type_id":"2","owner":"3","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-23"},"publish_date":"2008-01-23","publish_status":"0","recid":"5272","relation_version_is_last":true,"title":["Hypoglycemic effect of Aemotoxylon campechanum on streptozotocin (STZ)-induced diabetic rats"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-11-06T04:44:20.800652+00:00"}