@article{oai:toyama.repo.nii.ac.jp:00005270,
 author = {Yokozawa, Takako and Cho, EunJu and Rhyu, DongYoung and Nakagawa, Takako},
 issue = {3},
 journal = {和漢医薬学雑誌 = Journal of traditional medicines},
 month = {Jun},
 note = {application/pdf, 酸化ストレスは,腎疾患を含めた種々の疾患に関与していると考えられており,この酸化ストレスを防御することが出来れば,腎疾患の進行やそれに付随した合併症を予防することが出来るのではないかとの期待が高まっている。しかし,合成抗酸化剤は毒性と副作用が危惧され,近年,植物素材からの抗酸化物質が注目されているが,本稿では伝統薬物(地楡,温脾湯)と緑茶について紹介する。地楡とその成分のsaneguiin H-6は,NO由来の酸化障害に抗酸化因子として腎病態に作用し,温脾湯と(-)-epicatechin 3-O-gallateはONOO^-を消去して,ONOO^-からのフリーラジカルカスケードの産生を断ち切って,腎に好影響をもたらしていた。一方,緑茶ポリフェノールはin vitro, in vivoの実験系のいずれにおいても抗酸化効果を発揮するとともに,酸化亢進状態の透析患者に対しその有用性が示唆された。現在に至るまで腎疾患を狙ったフリーラジカル消去剤はおろか,画期的な治療薬すら開発されていないのが現状であるが,フリーラジカルの消去という観点からの新しいアプローチを提唱したい。
 Oxidative stress has been suggested to be one of the major causes of degenerative diseases, including renal failure. Therefore, antioxidant therapy to prevent the progression of renal failure and its related complications has attracted much attention. Although there are several synthetic antioxidants, in recent years, great effort has been focused on the use of natural phytochemicals present in herbs and foods because of the toxicity and side effects of synthetic antioxidants. This review summarizes the potential protective activities of two Chinese traditional medicines, Sanguisorbae Radix and Wen-Pi-Tang, and green tea, which are rich sources of polyphenols, against renal failure. Sanguisorbae Radix and its main active component sanguiin H-6 showed protective activity against NO-induced renal failure without toxicity. In addition, the Chinese prescription Wen-Pi-Tang and ECg regulated ONOO^- formation and exerted beneficial effects against ONOO^--induced oxidative injury and renal dysfunction. Green tea polyphenols also showed antioxidative activities in in vitro and in vivo experimental systems, and a clinical study suggested that they are useful for the treatment of renal injury. Even though the synthetic antioxidants are not always effective in improving renal failure due to their toxicity and/or side effects together with beneficial effects, Sanguisorbae Radix, Wen-Pi-Tang and green tea polyphenols displayed antioxidative activities against oxidative stress-induced renal failure without side effects. We expect the information presented in this review to help provide novel approaches, with low toxicity, to the prevention and effective treatment of renal diseases., Article},
 pages = {83--101},
 title = {Novel approaches to oxidative stress-induced renal failure : Therapeutic potentials of Sanguisorbae Radix, Wen-Pi-Tang and green tea},
 volume = {20},
 year = {2003}
}