{"created":"2023-07-25T09:06:58.404020+00:00","id":5261,"links":{},"metadata":{"_buckets":{"deposit":"03e35934-0efb-428e-9d1b-ae0c632cba49"},"_deposit":{"created_by":3,"id":"5261","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5261"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00005261","sets":["646:647:648"]},"author_link":["159143","159144"],"item_2_alternative_title_19":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Inhibitory Effects of Some Traditional Medicines on Proliferation of HIV-1 and Its Protease"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"529","bibliographicPageStart":"519","bibliographicVolumeNumber":"124","bibliographic_titles":[{"bibliographic_title":"藥學雜誌 : Journal of the Pharmaceutical Society of Japan (薬学雑誌）"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In attempts to discover anti-HIV agents from natural sources, various traditional medicine extracts were tested for their inhibitory effects on HIV-1 proliferation and its protease. An extract of the seeds of Croton tiglium showed potent inhibitory effects on the proliferation of HIV-1. The active principle was determined to be phorbol esters. Several derivatives of phorbol ester were evaluated for inhibition of proliferation as well as activation of protein kinase C (PKC). Of these compounds, 12-O-acetylphorbol 13-decanoate (6) showed the most potent inhibition of proliferation without activating PKC. Some triterpenes from the stems of Cynomorium songaricum and the woody part of Xan- thoceras sorbifolia showed inhibitory activity against HIV-1 protease. Various derivatives of oleanolic acid were synthe- sized and evaluated for their inhibitory activity against HIV-1 protease. Their inhibitory mechanism was also investigated.","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"159144","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nakamura, Norio"}]}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"社団法人日本薬学会"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00284903","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"316903","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中村, 憲夫"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"yakugakuzashi04-519.pdf","filesize":[{"value":"850.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"yakugakuzashi04-519.pdf","url":"https://toyama.repo.nii.ac.jp/record/5261/files/yakugakuzashi04-519.pdf"},"version_id":"d33432c1-e13b-4940-bd89-d965408a952c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HIV","subitem_subject_scheme":"Other"},{"subitem_subject":"phorbol ester","subitem_subject_scheme":"Other"},{"subitem_subject":"triterpene","subitem_subject_scheme":"Other"},{"subitem_subject":"HIV protease","subitem_subject_scheme":"Other"},{"subitem_subject":"AIDS","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"抗HIV活性を有する伝統薬物の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗HIV活性を有する伝統薬物の研究"}]},"item_type_id":"2","owner":"3","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-10"},"publish_date":"2008-01-10","publish_status":"0","recid":"5261","relation_version_is_last":true,"title":["抗HIV活性を有する伝統薬物の研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-11-06T04:44:39.881773+00:00"}