@article{oai:toyama.repo.nii.ac.jp:00005261,
 author = {中村, 憲夫},
 issue = {8},
 journal = {藥學雜誌 : Journal of the Pharmaceutical Society of Japan (薬学雑誌）},
 month = {Aug},
 note = {application/pdf, In attempts to discover anti-HIV agents from natural sources, various traditional medicine extracts were tested for their inhibitory effects on HIV-1 proliferation and its protease. An extract of the seeds of Croton tiglium showed potent inhibitory effects on the proliferation of HIV-1. The active principle was determined to be phorbol esters. Several derivatives of phorbol ester were evaluated for inhibition of proliferation as well as activation of protein kinase C (PKC). Of these compounds, 12-O-acetylphorbol 13-decanoate (6) showed the most potent inhibition of proliferation without activating PKC. Some triterpenes from the stems of Cynomorium songaricum and the woody part of Xan- thoceras sorbifolia showed inhibitory activity against HIV-1 protease. Various derivatives of oleanolic acid were synthe- sized and evaluated for their inhibitory activity against HIV-1 protease. Their inhibitory mechanism was also investigated., Article},
 pages = {519--529},
 title = {抗HIV活性を有する伝統薬物の研究},
 volume = {124},
 year = {2004}
}