@article{oai:toyama.repo.nii.ac.jp:00005253,
 author = {JEENAPONGSA, Rattima and Tohda, Michihisa and Watanabe, Hiroshi},
 issue = {4},
 journal = {和漢医薬学雑誌 = Journal of traditional medicines},
 month = {Aug},
 note = {application/pdf, Choto-san has been used for treatment of centrally regulated disorders such as dementia, hypertension, headache and vertigo. Our laboratory showed that Choto-san improved learning memory in ischemic mice. It is noticeable that Choto-san treated animals and animals that underwent conducting occlusion of common carotid arteries (2VO) operation slept longer than the normal animals. Therefore, this study aimed to clarify the effects of Choto-san and its related component; Chotoko and Choto-san without Chotoko on thiopental-induced sleeping time. The results show that Choto-san (0.3, 1 and 3 g/kg, p.o.) dose dependently prolonged the sleeping time induced by thiopental (50 mg/kg, i.p.). Chotoko (71.4 mg/kg, p.o.) and diazepam (1 mg/kg, i.p.) also increased the sleeping time while Choto-san without Chotoko (1 g/kg, p.o.) had no effect. This indicates that the effects of Choto-san and Chotoko, the main active constituent of Choto-san, may be mediated in part via their suppressive effect on the central nervous system of which the precise mechanisms remain unknown. 
 釣藤散の脳虚血マウスの学習行動改善作用を検討する過程において,釣藤散を投与した動物の睡眠時間が延長することを観察した。そこで本研究では,釣藤散およびその構成生薬・釣藤鈎ならびに,釣藤鈎をのぞいた釣藤散の,チオペンタール誘発睡眠に及ぼす効果を検討した。釣藤散は,0.3,1,3 g/kg 経口投与により用量依存的に50mg/kgチオペンタール腹腔内投与による正向反射消失時間を有意に延長した。釣藤鈎(71.4mg/kg-p.o.:釣藤散1g/kg中と等量)も有意な効果を示したが,釣藤鈎を除いた灼藤散(1g/kg)は無効であった。本結果より,釣藤散およびその構成生薬・釣藤鈎が中枢抑制作用を有することが推定された。, Article},
 pages = {165--167},
 title = {Effects of Choto-san and Chotoko on thiopental-induced sleeping time},
 volume = {20},
 year = {2003}
}