{"created":"2023-07-25T09:06:57.554402+00:00","id":5244,"links":{},"metadata":{"_buckets":{"deposit":"eea60278-51d5-43f3-b1d0-1d4fadfea824"},"_deposit":{"created_by":3,"id":"5244","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5244"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00005244","sets":["646:647:648"]},"author_link":["6558"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"66","bibliographicPageStart":"51","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"和漢医薬学雑誌 = Journal of traditional medicines"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We found that passive sensitization with anti-DNP IgE antibody followed by the challenge with DNFB to the mouse ear can induce the triphasic cutaneous reactions (ear swelling) of immediate phase response (IPR), late phase response (LPR) and very late phase response (vLPR), peaking at 1 h, 24 h and 8 days after the challenge, respectively. IPR was absent in mast cell-deficient mice but LPR was sufficiently observed, and vLPR was partly attenuated. LPR is a T cell-independent response, while vLPR is almost completely absent in T cell-deficient nude mice. Thus, the third phase response (vLPR) with massive infiltration of eosinophil actually represents an important inflammatory reaction mediated by T cells and partially mast cells. In this model, some Kampo formulations and synthetic anti-allergic agents inhibited the IgE-mediated triphasic cutaneous reaction. The inhibitory effects of the Kampo formulations on the triphasic cutaneous reaction were divided into several groups according to the efficacies for IPR/LPR/vLPR. For instance, the group consisting of formulations such as Tokaku-joki-to (Tao-He-Cheng-Qi-Tang,桃核承気湯), Ji-zuso-ippo (Zhi-Tou-Chuang-Yi-Fan, 治頭瘡一方), Sho-sei-ryu-to (Xiao-Qing-Long-Tang,小青竜湯) and Sho-saiko-to (Xiao-Chai-Hu-Tang, 小柴胡湯) significantly inhibited IPR, LPR and vLPR (i.e. +/+/+ group that showed inhibitory effects against the triphasic response), similar to the effect of prednisolone as a positive control. Oral administration of Yokukan-san (Yi-Gan-San,抑肝散), an anti-psychosis drug in Kampo medicine, attenuated the isolation stress-exacerbated triphasic skin reactions in a dose-dependent manner, while it had almost no effect on the cutaneous reactions in the unstressed group-housed mice. 0n the other hand, the i.p. administration of diazepam, a classic benzodiazepine receptor agonist, suppressed the enhanced IPR and LPR in socially isolated mice, but surprisingly stimulated vLPR in both stressed and unstressed mice, differing from the efficacy of Yokukan-san. This article focuses on the anti-allergic properties of Kampo formulations and describes the effect of some Kampo formulations on IgE-mediated triphasic skin reaction in group-housed or socially isolated mice. We also discuss the mechanism of the inhibitory action and the importance of the formulation and the constituent drugs in determining the efficacy.\n  抗DNP IgE抗体で受動感作したマウスの耳介にdinitro-fluorobenzene (DNFB)を塗布することにより,1時間,24時間および8日目をピークとする即時相(immediate phase response, IPR),遅発相(late phase response, LPR)および超遅発相(very late phase response, vLPR)の三相性皮膚反応が誘導されることを見い出した。IPRは肥満細胞が欠損したマウスでは認められず,LPRは明らかに観察され,vLPRは部分的に低下した。LPRはT細胞に非依存的な反応相であるが,一方,vLPRはT細胞欠損マウスではほぼ完全に消失した。このように,第三相目の皮膚反応(vLPR)は多数の好酸球の浸潤を伴い,主にT細胞と部分的に肥満細胞が関与した重要な炎症性反応であることを明らかにした。このモデルを用いて検討した結果,いくつかの漢方方剤および合成抗アレルギー薬がこのIgE介在性三相性皮膚反応を抑制することを見い出した。三相性皮膚反応に対する漢方方剤の抑制効果は,IPR, LPR, vLPRに対する効果に基づき,いくつかの群に分類された。たとえば,桃核承気湯,治頭瘡一方,小青竜湯および小柴胡湯のような方剤からなる群は,陽性対照として用いたステロイド剤prednisoloneと同様に,有意に三相性皮膚反応を抑制した(すなわち,+/+/+群)。抗不安作用を有する抑肝散を通常の群居飼育したマウスに経口投与した結果,三相性皮膚反応にほとんど効果を示さなかったが,隔離飼育によるストレス負荷マウスの増悪した三相性皮膚反応に対して,用量依存的な抑制効果を示した。一方,隔離飼育したマウスにbenzodiazepine受容体アゴニストであるdiazepamを腹腔内投与した結果,増悪したIRP, LPRは抑制されたが,vLPRに対する効果は隔離あるいは群居飼育にかかわらず,抑肝散の効果と明らかに異なり,さらなる増悪化か認められた。本総説では,漢方方剤の抗アレルギー作用に焦点をあて,通常の群居飼育あるいは隔離飼育マウスを用いて,いくつかの漢方方剤のIgE介在性三相性皮膚反応に及ぼす効果を記述する。さらに,抑制機序や漢方方剤やその構成生薬の効果発現における重要性について述べる。","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"6558","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000002280501","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000002280501"},{"nameIdentifier":"80133776","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000080133776"}],"names":[{"name":"済木, 育夫"}]}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"和漢医薬学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"rights: 本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12035198","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"18801447","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Saiki, Ikuo"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"JTradMed04-Saiki.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JTradMed04-Saiki.pdf","url":"https://toyama.repo.nii.ac.jp/record/5244/files/JTradMed04-Saiki.pdf"},"version_id":"d791ad7e-3933-42b9-a251-7c2f56bf0bb0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Kampo formulations","subitem_subject_scheme":"Other"},{"subitem_subject":"IgE-mediated triphasic cutaeous reaction","subitem_subject_scheme":"Other"},{"subitem_subject":"very late phase response","subitem_subject_scheme":"Other"},{"subitem_subject":"psychosocial stress","subitem_subject_scheme":"Other"},{"subitem_subject":"harmonization effect","subitem_subject_scheme":"Other"},{"subitem_subject":"SHO","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Kampo formulations and allergic inflammatory diseases : Efficacy for murine IgE-mediated triphasic cutaneous reaction","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Kampo formulations and allergic inflammatory diseases : Efficacy for murine IgE-mediated triphasic cutaneous reaction"}]},"item_type_id":"2","owner":"3","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-12-18"},"publish_date":"2007-12-18","publish_status":"0","recid":"5244","relation_version_is_last":true,"title":["Kampo formulations and allergic inflammatory diseases : Efficacy for murine IgE-mediated triphasic cutaneous reaction"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-11-06T04:44:36.218941+00:00"}