@article{oai:toyama.repo.nii.ac.jp:00005241,
 author = {SUNTORNSUK, Leena and Koizumi, Keiichi and Saitoh, Yurika and Nakamura, ElianeShizuka and KAMMASUD, Naparat and VAJARAGUPTA, Opa and Saiki, Ikuo},
 issue = {2},
 journal = {和漢医薬学雑誌 = Journal of traditional medicines},
 month = {Apr},
 note = {application/pdf, 21st Century COE Program, Toyama Medical and Pharmaceutical University, We investigated the anti-angiogenic effect of curcumin, curcumin ethylenediamine derivative (curcumin ED) and curcumin ethylenediamine manganese complex (curcumin EDMn) through the inhibition of the formation of tube-like structures by human umbilical vascular endothelial cells (HUVEC). Curcumin, curcumin ED, curcumin EDMn did not show cytotoxicity to HUVEC at concentrations equal and lower than 10 μM. At the concentration of 10 μM,curcumin, curcumin ED and curcumin EDMn inhibited the tube formation by approximately 94%, 40% and 65%, respectively. These results suggest that curcumin ED and curcumin EDMn might be useful as anti-angiogenic drugs in addition to their anti-lipid peroxidase and superoxide dismutase activities as described in our previous studies.
 クルクミン(curcumin),クルクミン・エチレンジアミン誘導体(curcumin ED)及びそのマンガン複合体(curcumin EDMn)を用いて,ヒト臍帯静脈内皮細胞の管腔様構造の形成能を指標にして血管新生阻害効果を検討した。10μMのcurcumin, curcumin ED及びcurcumin EDMn は,管腔様構造の形成をそれぞれ94%,40%及び65%程度阻害した。これらの結果は,curcuminとともにcurcumin ED及びcurcumin EDMnが以前に報告した抗脂質過酸化作用やスーパーオキシドジスムターゼ活性を有することに加えて,血管新生の阻害薬として有効であることが示唆された。, Article},
 pages = {94--99},
 title = {Anti-angiogenic effect of curcumin, curcumin ethylenediamine derivative and curcumin ethylenediamine manganese complex},
 volume = {21},
 year = {2004}
}