{"created":"2023-07-25T09:06:56.935688+00:00","id":5230,"links":{},"metadata":{"_buckets":{"deposit":"aabfe33c-ddf5-4485-85ea-52f21aceea34"},"_deposit":{"created_by":3,"id":"5230","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5230"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00005230","sets":["646:647:648"]},"author_link":["6030","160496","160495"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-02","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"38","bibliographicPageStart":"31","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"Journal of traditional medicines"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"当帰芍薬散は古来より婦人科領域で使われている代表的漢方方剤の1つである。また下垂体摘出ラット卵巣では卵胞の発育遅延、骨密度の低下を引き起こすことが知られている。そこで我々は,ラットの下垂体摘出後,当帰芍薬散の経口投与を1週間行い,投与後の卵巣を解析した。下垂体摘出による卵巣重量低下を当帰芍薬散は回復させなかったが,子宮重量低下に対する回復はみられた。また,下垂体摘出により卵巣内StAR蛋白質のmRNA発現量は減少したが,当帰芍薬散を投与することにより発現量の回復がみられた。下垂体アデニル酸シクラーゼ活性化ポリペプチド受容体(PAC_1),プロゲステロン受容体(PR)のmRNA発現量は下垂体摘出により上昇したが,当帰芍薬散はこれを抑制した。しかし,エストロゲン受容体α(ERα)のmRNA発現量の変化は見られなかった。さらに組織学的観察より,当帰芍薬散は卵胞発達を促進する傾向が見られた。また,当帰芍薬散は骨代謝のマーカーである尿中DPDレベルの上昇を抑制した。以上の結果から,当帰芍薬散は卵巣における卵胞の発達を促進し,下垂体ホルモン由来の骨代謝を抑制することが示唆された。\n\nThe prescription Tokishakuyakusan (TS; Dang-Gui-Shao-Yao-San in Chinese) is widely used in traditional Chinese medicine. Since delay of ovarian follicle maturation and fall of bone density are known in hypophysectomized (HPX) rats, we investigated the effects of TS on ovaries in HPX rats. Although TS did not recover the ovary weight decreased by hypophysectomy, it recovered the uterine weight. Two weeks after hypophysectomy, the expression of steroidogenic acute regulatory protein (StAR) mRNA was decreased, but recovered by administration of TS. On the other hand, the expression of pituitary adenylate-cyclase activating polypeptide receptor type I (PAC_1) and progesterone receptor (PR) mRNA was increased, but reduced by administration of TS. However, the expression of estrogen receptor α (ERα) mRNA did not synchronize with PAC_1 mRNA and PR mRNA expression. Moreover, TS was demonstrated to promote the follicle maturation by histrogical analysis, and to decrease significantly the urinary deoxypyridinoline (DPD) level. These findings suggest that TS promotes the maturation of follicles and suppresses the bone metabolism associated with pituitary hormones.","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Journal of traditional medicines 24, 31-38.(2007)","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"和漢医薬学会"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"18801447","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Chung, MiHwa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tohda, Michihisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hattori, Masao"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"JTrMed2431.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JTrMed2431.pdf","url":"https://toyama.repo.nii.ac.jp/record/5230/files/JTrMed2431.pdf"},"version_id":"898eb48c-9727-430e-80a9-f5eac5fad8fe"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Tokishakuyakusan","subitem_subject_scheme":"Other"},{"subitem_subject":"Kampo medicine","subitem_subject_scheme":"Other"},{"subitem_subject":"hypophysectomy","subitem_subject_scheme":"Other"},{"subitem_subject":"ovary","subitem_subject_scheme":"Other"},{"subitem_subject":"bone metabolism","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Tokishakuyakusan on the ovary in hypophysectomized rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Tokishakuyakusan on the ovary in hypophysectomized rats"}]},"item_type_id":"2","owner":"3","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-11-27"},"publish_date":"2007-11-27","publish_status":"0","recid":"5230","relation_version_is_last":true,"title":["Effects of Tokishakuyakusan on the ovary in hypophysectomized rats"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-11-06T04:44:32.941653+00:00"}