@article{oai:toyama.repo.nii.ac.jp:00005224,
 author = {Jo, Michiko and NAKAMURA, Norio and KUROKAWA, Masahiko and Komatsu, Katsuko and Shiraki, Kimiyasu and Hattori, Masao},
 issue = {6},
 journal = {和漢医薬学雑誌 = Journal of traditional medicines},
 month = {Dec},
 note = {application/pdf, 雲南省及びチベット自治区で採集した168種の中国少数民族薬物の水及びメタノールエキスの抗HSV-1活性をプラーク減少法を用いて検討した。24種のエキスに抗HSV-1活性が認められ, さらにHSV-1を経皮感染させたマウスを用い, これらのエキスを約1週間経口投与した。その結果, Terminalia chebula (T42), Tripterygium hypoglaucum (Y42M), Moghania philippinensis (Y86M)のメタノールエキス, 及び, Tripterygium hypoglaucum (Y44H)の水エキスに有意な皮膚病変進展の遅延効果が認められた。また, Cassia fistula (T59), Choerospondias axillaries (T73)のメタノールエキス, 及び, Begonia evansiana (Y27H), Maytenus fookerii (Y60H), Potentilla griffithii (Y63H)の水エキスに生存期間の延長が認められた。これらのエキスには, 抗HSV-1活性を示す化合物が含まれており, 新規抗HSV-1化合物の探索に有用であると思われる。
One hundred and sixty-eight traditional Chinese medicines collected in the Yunnan and Tibetan provinces were screened for their anti-herpes simplex type 1 (HSV-1) activity by using a plaque reduction assay using Vero cells. Of these, 24 extracts exhibited appreciable inhibitory activities against HSV-1. They were further examined for their therapeutic efficacies in mice infected with HSV-1; mice were infected cutaneously with HSV-1 and the extracts were orally administrated three times daily. Among them, nine extracts of Terminalia chebula (T42), Tripterygium hypoglaucum (Y42M), and Moghania philippinensis (Y86M), and a water extract of Tripterygium hypoglaucum (Y44H) delayed the development and progression of skin lesions. Methanol extracts of Cassia fistula (T59), and Choerospondias axillaries (T73), and water extracts of Begonia evansiana (Y27H), Maytenus fookerii (Y60H) and Potentilla griffithii (Y63H) showed therapeutic effects. These extracts may be candidates for the development of anti-HSV-1 compounds., Article},
 pages = {321--328},
 title = {Anti-herpes simplex virus activities of traditional Chinese medicines, used in Yunnan and Tibetan provinces of China},
 volume = {22},
 year = {2005}
}