@misc{oai:toyama.repo.nii.ac.jp:00005170,
 author = {大崎, 緑男},
 month = {Mar},
 note = {application/pdf, [Part. 1]
Background: Cysteinyl leukotrienes (LTs) and thromboxane A_2(TXA_2) are known to play an essential role in the pathogenesis of atopic asthma.
However, their role in nonatopic asthma has not as yet been clarified.
The objectives of this study were to define (1) the participation or LTs and TXA_2 in nonatopic asthma and (2) the relationship between LTs and TXA_2 in asthma attacks.
Methods: Urinary excretion or leukotriene E_4 (LTE_4) and 11-dehydrothromboxane B_2 (11DTXB_2) was measured in 10 atopic and 10 nonatopic asthmatics who were admitted to hospital with either an acute asthma attack or status asthmaticus.
Results: In atopic asthmatics, urinary excretion of LTE_4 and 11DTXB_2 was significantly higher on admission with an asthma attack, and returned to control levels when the patients were in the improved state (179±29 to 65±16 ng/day in LTE_4, 1,085±250 to 440±90 ng/day in 11DTXB_2).
Similar findings were observed in nonatopic asthmatics (148±13 to 61±11 ng/day in LTE_4. 1,089±206 to 457±60 ng/day in 11DTXB_2).
However, when the individual data during the attack were analyzed, there was no correlation between urinary excretion of LTE_4 and that of 11DTXB_2 in both types or asthma.
Conclusion: Both LTs and TXA_2 may be implicated in the pathogenesis of thc nonatopic as well as the atopic type of asthma, but no correlation between these two metabolites was observed in the individuals., [Part. 2]
The objective of this study was to define the participation of cysteinyl leukotrienes (LTs) or thromboxane Aj in the pathogenesis of aspirinsensitive asthma (ASA).
Leukotriene E4 (LTE4) and 11-dehydrothromboxane Bj (llDTXBj) values in spot urine were measured in 22 asthmatics with a history of aspirin sensitivity and in 17 without such a history (non-aspirin-sensitive asthma [NASA]) in the outpatient clinic.
The urinary LTE4 value was significantly higher in ASA patients than in NASA (340±47 vs 65±15 pg/mg-cr, P<0.001), but there was no significant difference in urinary IIDTXB2 between the two groups (891±77 vs 657±90 pg/mg-cr).
A high value of LTE4 was not associated with type of asthma, severity of disease, oral prednisolone treatment, sex, or age.
A higher value of IIDTXB7 was observed in the atopic type than the nonatopic type in ASA (1086±lfl vs 6971147 pg/mg-cr, P<0.05).
No correlation was observed between urinary LTE4 and llDTXBj in either ASA or NASA.
In conclusion, LTs may play an important role in the pathogenesis of ASA, and TXA2 in the pathogenesis of the atopic type in ASA., Article, 富山医科薬科大学・博士(医学)・乙第363号・大崎緑男・1998/3/11, lnternational Archives of Allergy lmmunology, 114 : 373-378, Allergy, 52 : 470-473　に掲載},
 title = {The clinicopathological significance of determination of urinary leukotriene E_4 and 11-dehydrothromboxane B_2 in patients with bronchial asthma},
 year = {1998}
}