@phdthesis{oai:toyama.repo.nii.ac.jp:00005160,
 author = {Matsui, Mie and Kurachi, Masayoshi and Yuasa, Satoru and Aso, Mitsuo and Tonoya, Yasuhiro and Nohara, Shigeru and Saitoh, Osamu},
 month = {Jun},
 note = {<Study 1>
This study examined tracking eye movements on predetermined stationary targets inpatients with schizophrenia spectrum dis order.
The targets were 8 black points or 8 arabics' numbered points placed on the circumference of a circle.
Self-paced eye movements during clockwise tracking of these points by 23 patients and 23 normal controls were recorded using an infrared eye-mark recorder.
Eye movements were an alyzed at two settings : first, when "fixation point" was defined as a point at which a gaze was held for at least 200 msec, and second, when held for at least 100 msec.
The results indicated that at the 200 msec setting schizophrenic patients track with significantly fewer correct scores and more deviant scores than controls under black-point conditions.
At the 100-msec setting, however, the correct scores of the patients were not significantly different from those of the controls, although the patients displayed more aberrant paths than the controls.
The superfluous fixations in the patients improved significantly under numbered-point conditions, but patients still achieved lower correct scores than the controls. Four of the 23 patients exhibited centering (aberrant path directed toward the center point), suggesting immature control of eye movements under black-point conditions but not numbered-point conditions.
These results suggest that some schizophrenic patients viewed the targets too quickly and that they have impaired directed attention, which can be improved by cues, and may have impaired preprogramming of eye movements, which is not improved by external cues., <Study 2>
This study examined saccadic eye movements using simple stationary targets, in schizophrenic patients.
The targets were 8 black points or 8 arabic-numbered points placed in randomized order on the circumference of a circle.
Self-paced eye movements during clockwise tracking of these points, by 23 patients and 23 controls, were recorded using an infrared eye-mark recorder.
Then the relationship between the saccades and clinical syndromes was investigated. Finally, the relationship between the performance of the saccades and resting regional cerebral blood flow (rCBF) was examined using single photon emission computed tomography with 99mTc-hexamethyl propyleneamine oxime (HMPAO).
The results indicate that patients track with significantly fewer correct scores and more deviant scores than controls, in agreement with our previous study.
There were two groups of patients : an ordinary group who obtained a full target hitting score at a 200 ms setting and a fast group who obtained the full score at 100 ms but not at 200 ms.
Some patients displayed significantly more hypermetria than controls.
Significant correlations were found between alienation syndrome (auditory hallucination and disturbance of the self) and correct scores, or delusion syndrome and deviant score.
With respect to relative rCBF, fast group patients showed significantly decreased rCBF in the left limbic and inferior parietal areas as compared with ordinary group patients.
These findings suggest that some schizophrenic patients view the stationary targets too fast and this may be related to dysfunction in the limbic-parietal association area in the left hemisphere., Article, 富山医科薬科大学・博士(医学)・乙第283号・松井三枝・1995/6/28},
 school = {富山医科薬科大学},
 title = {Impaired saccadic eye movements in schizophrenic patients},
 year = {1995}
}