{"created":"2023-07-25T09:06:52.129358+00:00","id":5149,"links":{},"metadata":{"_buckets":{"deposit":"3737ed3f-9119-4f40-984c-8770a9c0c76e"},"_deposit":{"created_by":3,"id":"5149","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5149"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00005149","sets":["640:641:642"]},"author_link":["158819","158820"],"item_9_alternative_title_19":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"イヌ心筋単一細胞の収縮反応および電気生理学的性質に及ぼすセボフルレンの作用"}]},"item_9_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1993-03-10","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_9_date_granted_64":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"1993-03-10"}]},"item_9_degree_grantor_62":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"富山医科薬科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13202","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_9_degree_name_61":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Sevoflurane is a potent anesthetic that is widely used due to its efficacy in preventing arrhythmias associated with epinephrine.\nThe mechanism of negative inotropic effect of sevoflurane was examined in the present study on canine single ventricular myocytes.\nThe effects of sevoflurane on contractile response, membrane potential, membrane ionic currents and intracellular cyclic AMP were studied.\nContractions were measured by a video-edge detector and membrane ionic currents were recorded using whole-cell voltage clamp technique.\nSevoflurane, in concentrations ranging from 1.0% to 4.0%, decreased contraction of single ventricular cells.\nThese inhibitory effects on the contractile response were dose-dependant and reversible.\nIn normal Tyrode solution, sevoflurane decreased the plateau of action potentials and shortened the durations.\nIn high-K^+ (26mM) Tyrode solution, the duration of slow action potential was shortened.\nVoltage-clamp experiment with single canine ventricular cells revealed that sevoflurane reduced the peak Ca^<2+> currents (I_<Ca>).\nThese inhibitory effects of sevoflurane on I_<Ca> did not show use-dependent block.\nOn the other hand, sevoflurane depressed Na^+ currents (I_<Na>) only in high concentration (4.0%) and had no effect on the inward rectifier K^+ currents (I_<Kl>).\nThe inhibition of I_<Ca> was not associated with changes in intracellular concentration of cyclic AMP except at a high dose (4.0%).\nThese results suggest that the negative inotropic effect of sevoflurane is mediated via inhibition of I_<Ca> in canine ventricular cells.","subitem_description_type":"Abstract"}]},"item_9_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"富山医科薬科大学・博士(医学)・甲第172号・畠山登・1993/3/10","subitem_description_type":"Other"}]},"item_9_dissertation_number_65":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第172号"}]},"item_9_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"158820","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hatakeyarna, Noboru"}]}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.11501/3065404","subitem_identifier_reg_type":"JaLC"}]},"item_9_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"畠山, 登"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"000000257489.pdf","filesize":[{"value":"6.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"000000257489.pdf","url":"https://toyama.repo.nii.ac.jp/record/5149/files/000000257489.pdf"},"version_id":"c249ba93-64eb-4233-ab7f-5ce500edd4b0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Anesthetics","subitem_subject_scheme":"Other"},{"subitem_subject":"volatile","subitem_subject_scheme":"Other"},{"subitem_subject":"sevoflurane","subitem_subject_scheme":"Other"},{"subitem_subject":"canine heart","subitem_subject_scheme":"Other"},{"subitem_subject":"single cell","subitem_subject_scheme":"Other"},{"subitem_subject":"calcium current","subitem_subject_scheme":"Other"},{"subitem_subject":"sodium current","subitem_subject_scheme":"Other"},{"subitem_subject":"cyclic AMP","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Effects of sevoflurane on contractile response and electrophysiological properties in single cardiac myocytes of dog","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of sevoflurane on contractile response and electrophysiological properties in single cardiac myocytes of dog"}]},"item_type_id":"9","owner":"3","path":["642"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-02-07"},"publish_date":"2013-02-07","publish_status":"0","recid":"5149","relation_version_is_last":true,"title":["Effects of sevoflurane on contractile response and electrophysiological properties in single cardiac myocytes of dog"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T15:02:30.363363+00:00"}