{"created":"2023-07-25T09:06:51.798533+00:00","id":5144,"links":{},"metadata":{"_buckets":{"deposit":"208a0a2c-d82d-4819-8cb9-fb335c2b7959"},"_deposit":{"created_by":3,"id":"5144","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5144"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00005144","sets":["640:641:642"]},"author_link":["158810","158809"],"item_9_alternative_title_19":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ヒト黄色靱帯における石灰化抑制因子"}]},"item_9_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-10-09","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_9_date_granted_64":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"1991-10-09"}]},"item_9_degree_grantor_62":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"富山医科薬科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13202","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_9_degree_name_61":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To examine the presence of substances which inhibit calcification in human ligamentum flavum, the calcification inhibitory effect of human ligamentum flavum extract obtained by extraction of the tissue with 3% Na_2HPO_4 was determined by the in vitro calcium uptake of the ligamentum flavum matrix.\nIn addition, grafts of extracted and non-extracted dry ligamentum flavum matrices were transplanted into the dorsal muscles of rats, and calcification in the grafts was examined radiologically and histochemically.\nIn order to determine whether or not component cells of human ligamentum flavum produce calcification inhibitors, ligamentum flavum cells were cultured, and thecrystal inhibitor activity of the culture medium was measured by the seed test using hydroxyapatite as the nucleus of precipitation.\nThe calcification reaction system demonstrated that the ligamentum flavum extract contains an inhibitory factor for calcium uptake by the ligamentum flavum matrix.\nThe seed test revealed that human ligamentum flavum cells produce calcification inhibitor activity.\nThe inhibitor activity was fractionated into two peaks by gel filtration of the culture medium.","subitem_description_type":"Abstract"}]},"item_9_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"富山医科薬科大学・医学博士・乙第144号・丸田喜美子・1991/10/9","subitem_description_type":"Other"}]},"item_9_dissertation_number_65":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第144号"}]},"item_9_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"158810","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Maruta, Kimiko"}]}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.11501/3087115","subitem_identifier_reg_type":"JaLC"}]},"item_9_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"丸田, 喜美子"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"000000247304.pdf","filesize":[{"value":"7.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"000000247304.pdf","url":"https://toyama.repo.nii.ac.jp/record/5144/files/000000247304.pdf"},"version_id":"8149bdd4-5adf-4b55-9881-ca4aa535f917"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Human ligamentum flavum","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcification","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcification inhibitors","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Calcification inhibitors in human ligamentum flavum","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Calcification inhibitors in human ligamentum flavum"}]},"item_type_id":"9","owner":"3","path":["642"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-02-07"},"publish_date":"2013-02-07","publish_status":"0","recid":"5144","relation_version_is_last":true,"title":["Calcification inhibitors in human ligamentum flavum"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T15:02:34.269553+00:00"}