{"created":"2023-07-25T09:06:51.534931+00:00","id":5140,"links":{},"metadata":{"_buckets":{"deposit":"60dc0d08-2eb2-43a0-9510-47b86fb6102c"},"_deposit":{"created_by":3,"id":"5140","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5140"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00005140","sets":["640:641:642"]},"author_link":["158792","158791"],"item_9_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989-10-25","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_9_date_granted_64":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"1989-10-25"}]},"item_9_degree_grantor_62":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"富山医科薬科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13202","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_9_degree_name_61":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"副腎髄質から分泌されるカテコールアミンは，標的臓器の血管平滑筋のカテコールアミン受容体と結合し主としてvasoactiveな効果を発現する。\nカテコールアミン受容体は，様々な組織に幅広く存在すると考えられている。\n副腎皮質においてはα受容体刺激によりアルドステロン分泌が増強することからα受容体が存在する可能性が推測されている。\n交感神経節後線維末端では，カテコールアミン分泌に対するnegative feedback機構にシナプス前アドレナリン作動性α_2受容体が関与するといわれている。\n交感神経線維と副腎髄質のクローム親和性細胞は，その発生原基が同一であることから，副腎髄質からのカテコールアミシ分泌をmodulateするα受容体が副腎においても存在することが推測される。\nそこで，われわれは，^3H-prazosin，^3H-yohimbineを用いたradioligand receptor assayという直接的な方法によりラットならびにヒト副腎においてα_1，α_2受容体が存在するか否かを検討した。","subitem_description_type":"Abstract"}]},"item_9_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"富山医科薬科大学・医学博士・乙第106号・古田秀勝・1989/10/25","subitem_description_type":"Other"}]},"item_9_dissertation_number_65":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第106号"}]},"item_9_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"158792","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Furuta, Hidekatsu"}]}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.11501/3085499","subitem_identifier_reg_type":"JaLC"}]},"item_9_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"古田, 秀勝"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"000000240784.pdf","filesize":[{"value":"7.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"000000240784.pdf","url":"https://toyama.repo.nii.ac.jp/record/5140/files/000000240784.pdf"},"version_id":"e8a20e8e-3c68-4980-ae9e-8ecc02ce3c5f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"カテコールアミン","subitem_subject_scheme":"Other"},{"subitem_subject":"副腎髄質","subitem_subject_scheme":"Other"},{"subitem_subject":"α受容体","subitem_subject_scheme":"Other"},{"subitem_subject":"α_1受容体","subitem_subject_scheme":"Other"},{"subitem_subject":"α_2受容体","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"正常ラット副腎およびヒト副腎におけるカテコールアミンα受容体の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"正常ラット副腎およびヒト副腎におけるカテコールアミンα受容体の研究"}]},"item_type_id":"9","owner":"3","path":["642"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-02-07"},"publish_date":"2013-02-07","publish_status":"0","recid":"5140","relation_version_is_last":true,"title":["正常ラット副腎およびヒト副腎におけるカテコールアミンα受容体の研究"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T15:02:37.043702+00:00"}