{"created":"2023-07-25T09:06:51.403317+00:00","id":5138,"links":{},"metadata":{"_buckets":{"deposit":"53c1ff0d-98d5-4d37-927e-5c45deb3ea60"},"_deposit":{"created_by":3,"id":"5138","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"5138"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00005138","sets":["640:641:642"]},"author_link":["158786","158784","158785","158788","158787"],"item_9_alternative_title_19":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ヒト非肥満インスリン非依存型糠尿病の動物モデルN0Nマウスのプレプ口インスリン遺伝子のクローニングとその構造解析"}]},"item_9_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-03-20","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_9_date_granted_64":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"1990-03-20"}]},"item_9_degree_grantor_62":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"富山医科薬科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13202","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_9_degree_name_61":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_9_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We have proposed in the previous study that the NON mouse is an animal model suitable for studying human non-obese, non-insulin-dependent diabetes mellitus, and we have shown that hypoinsulinemia in the NON mouse was associated with reduced levels of insulin mRNA in their pancreas.\nThese results suggest that structural alternation of the insulin gene may occur in this mouse.\nIn the present study, to corroborate this possibility, we attempted to isolate and characterize the insulin gene of the NON mouse.\nComparison with structures of the insulin I and II genes of the BALB/c mouse demonstrated that the NON mouse has two non-allelic insulin genes, encoding separately insulin I and II.\nThe nucleotide sequences of the NON mouse insulin genes, including 5'-transcriptional regulatory region and exon/intron organization, do not differ from the reported sequences of the insulin I and II genes of the BALB/c mouse.\nWe can, however, point out that about 100 base pairs additional sequence and 7 point mutations are involved in further upstream 5'-flanking region of, and 3 point mutations in 3'-flanking region of the insulin II gene of the NON mouse.\nWe conclude that the reduced expression of the insulin genes in the NON mouse is due to neither the structural change in the known transcriptional regulatory elements nor occurrence of the abnormal and unstable insulin mRNA.\nRole of the 5'-upstream additional sequence for the insulin II gene expression remains to be elucidated.","subitem_description_type":"Abstract"}]},"item_9_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_9_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"富山医科薬科大学・医学博士・甲第117号・沢丞・1990/3/20","subitem_description_type":"Other"}]},"item_9_dissertation_number_65":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第117号"}]},"item_9_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"158785","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Sawa, Tasuku"}]},{"nameIdentifiers":[{"nameIdentifier":"158786","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ohgaku, Seiji"}]},{"nameIdentifiers":[{"nameIdentifier":"158787","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Morioka, Hisao"}]},{"nameIdentifiers":[{"nameIdentifier":"158788","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yano, Saburo"}]}]},"item_9_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.11501/3054750","subitem_identifier_reg_type":"JaLC"}]},"item_9_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"沢, 丞"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-17"}],"displaytype":"detail","filename":"000000240750.pdf","filesize":[{"value":"9.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"000000240750.pdf","url":"https://toyama.repo.nii.ac.jp/record/5138/files/000000240750.pdf"},"version_id":"1b200933-3d84-4960-a279-fbeed24473b4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"NON mouse","subitem_subject_scheme":"Other"},{"subitem_subject":"non-obese","subitem_subject_scheme":"Other"},{"subitem_subject":"non-insulin-dependent","subitem_subject_scheme":"Other"},{"subitem_subject":"diabetes","subitem_subject_scheme":"Other"},{"subitem_subject":"Non-insulindependent diabetes mellitus","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Molecular Cloning and DNA Sequence Analysis of Preproinsulin Genes in the NON Mouse, an Animal Model of Human Non-Obese, Non-Insulin-Dependent Diabetes Mellitus","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Molecular Cloning and DNA Sequence Analysis of Preproinsulin Genes in the NON Mouse, an Animal Model of Human Non-Obese, Non-Insulin-Dependent Diabetes Mellitus"}]},"item_type_id":"9","owner":"3","path":["642"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-02-07"},"publish_date":"2013-02-07","publish_status":"0","recid":"5138","relation_version_is_last":true,"title":["Molecular Cloning and DNA Sequence Analysis of Preproinsulin Genes in the NON Mouse, an Animal Model of Human Non-Obese, Non-Insulin-Dependent Diabetes Mellitus"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T15:02:36.272268+00:00"}