{"created":"2023-07-25T09:04:59.126946+00:00","id":2933,"links":{},"metadata":{"_buckets":{"deposit":"d8e9d1eb-424d-4085-b5ec-aa444b6d7c37"},"_deposit":{"created_by":3,"id":"2933","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2933"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00002933","sets":["439:470:471:487:491"]},"author_link":["158518","9864","158520"],"item_3_alternative_title_19":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Differentral Regulation of Lyn in Fcs RI Raft or BCR Raft"}]},"item_3_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"37","bibliographicPageEnd":"13","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"研究紀要 : 富山大学杉谷キャンパス一般教育"}]}]},"item_3_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"I型アレルギーの発症に至る最終的なエフェクター細胞はマスト細胞/好塩基球である。これらの細胞が活性化するための主たる経路はFcε RIシグナルによるものである。このシグナルの起点にはSrc-familykinase(SFK)であるLynが位置している。現在、Lynの活性化メカニズムはほとんど不明であり、この活性化メカニズムを解明することはI型アレルギーの治療にも大きく貢献しうると考えられる。本研究はLynの活性化機構の解析を試みたものである。実験はマスト細胞様ラット好塩基球細胞株RBL-2H3を材料として、B細胞株WEHI-231のシグナル伝達と比較解析を行った。これら細胞のシグナル発火前後におけるLyn自身のチロシンリン酸化動態について比較解析を行うことにより、マスト細胞に独自のLynの活性化パターンを見出した。","subitem_description_type":"Abstract"}]},"item_3_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_3_description_6":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"研究紀要 : 富山大学杉谷キャンパス一般教育,第37号,2009.12.25,pp.1-13","subitem_description_type":"Other"}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"158520","nameIdentifierScheme":"WEKO"}],"names":[{"name":"OHSHIMA, Kana"}]},{"nameIdentifiers":[{"nameIdentifier":"9864","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000237944393","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000237944393"},{"nameIdentifier":"00233742","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000000233742"}],"names":[{"name":"Katagiri, Tatsuo"}]}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15099/00002927","subitem_identifier_reg_type":"JaLC"}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"[富山大学杉谷キャンパス一般教育]"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12190328","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1882045X","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_22":{"attribute_name":"国立国会図書館分類","attribute_value_mlt":[{"subitem_subject":"ZV1","subitem_subject_scheme":"NDLC"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大島, 香菜"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"片桐, 達雄"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-15"}],"displaytype":"detail","filename":"TMPU_JLAS_37_01_Page001-013.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"TMPU_JLAS_37_01_Page001-013.pdf","url":"https://toyama.repo.nii.ac.jp/record/2933/files/TMPU_JLAS_37_01_Page001-013.pdf"},"version_id":"5759bec7-c1d5-476a-8acb-63a33c2fcef5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"マスト細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"Raft","subitem_subject_scheme":"Other"},{"subitem_subject":"シグナル伝達","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"マスト細胞のRaftを介したシグナル伝達の解析 : RBL-2H3細胞のFcεRI raftにおけるLynの制御機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マスト細胞のRaftを介したシグナル伝達の解析 : RBL-2H3細胞のFcεRI raftにおけるLynの制御機構"}]},"item_type_id":"3","owner":"3","path":["491"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-04-11"},"publish_date":"2013-04-11","publish_status":"0","recid":"2933","relation_version_is_last":true,"title":["マスト細胞のRaftを介したシグナル伝達の解析 : RBL-2H3細胞のFcεRI raftにおけるLynの制御機構"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T12:47:47.318994+00:00"}