{"created":"2023-07-25T09:04:57.030095+00:00","id":2883,"links":{},"metadata":{"_buckets":{"deposit":"aa481d45-a554-4e84-9922-7a215abd84bd"},"_deposit":{"created_by":3,"id":"2883","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2883"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00002883","sets":["439:470:471:472:486"]},"author_link":["9743","158432","158430"],"item_3_alternative_title_19":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Hydrolyzable Tannins in Bark of Rhus trichocarpa Selectively Inhibit Eukaryotic Glucosamine-6-phosphate Synthase (GFAT) from Saccharomyces cerevisiae"}]},"item_3_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-12","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"71","bibliographicPageStart":"61","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"研究紀要 : 富山医科薬科大学一般教育"}]}]},"item_3_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"糖尿病による高血糖状態はへキソサミン合成経路を異常に亢進させ,様々な糖尿病合併症の発症と密接に関係している。本研究では,この合成経路の律速酵素であるグルコサミン-6-リン酸合成酵素(L-グルタミン:D-フルクトース-6-リン酸アミドトランスフェラーゼ;GFAT)の活性を阻害するヤマウルシ(Rhus trichocarpa MIQ.)樹皮の成分の単離・精製と構造解析を行い,この植物に含まれる阻害物質は,加水分解件タンニンに属する1,2,3,4,6-pentagalloyl-β-D-glucoseと3-m-digalloyl-1,2,4,6-tetragalloyl-β-D-glucoseであることを見いだした。また,これらの加水分解性タンニンによる阻害作用は選択的で,酵母由来の真核生物型GFATに対しては顕著な阻害効果を示したが,大腸菌由来の原核生物型GFATの活性にはほとんど影響を及ぼさなかった。今回の実験結果並びに文献に基づいて,加水分解性タンニンによる真核生物型GFATの阻害メカニズムについて考察する。","subitem_description_type":"Abstract"}]},"item_3_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9743","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000030303233","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000030303233"},{"nameIdentifier":"30303233","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000030303233"}],"names":[{"name":"ARADATE, Tadashi"}]},{"nameIdentifiers":[{"nameIdentifier":"158432","nameIdentifierScheme":"WEKO"}],"names":[{"name":"OZAKI, HirokiS."}]}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15099/00002877","subitem_identifier_reg_type":"JaLC"}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"富山大学"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN0017517X","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0387-6373","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"荒舘, 忠"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"尾崎, 宏基"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-15"}],"displaytype":"detail","filename":"33iaradate.pdf","filesize":[{"value":"660.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"33iaradate.pdf","url":"https://toyama.repo.nii.ac.jp/record/2883/files/33iaradate.pdf"},"version_id":"479e5da8-b0db-4e20-9326-afbf5a26a885"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"加水分解性タンニン","subitem_subject_scheme":"Other"},{"subitem_subject":"真核生物型GFAT","subitem_subject_scheme":"Other"},{"subitem_subject":"ヤマウルシ樹皮","subitem_subject_scheme":"Other"},{"subitem_subject":"糖尿病","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin 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