{"created":"2023-07-25T09:04:53.741033+00:00","id":2806,"links":{},"metadata":{"_buckets":{"deposit":"44dcd72c-6b93-4286-80c8-883284911324"},"_deposit":{"created_by":3,"id":"2806","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2806"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00002806","sets":["439:467:468:469"]},"author_link":["158226","158224","158220","158223","158227","9585","158222","158225","158221"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"244","bibliographicPageStart":"239","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"和漢医薬学雑誌 = Journal of traditional medicines"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The anti-allergic activity of Perilla glycopeptide (Pe-GP) isolated from dried Perilla frutescens BRH-TON leaves was investigated. Pe-GP was found to be effective in inhibiting histamine release from IgE-sensitized rat peritoneal mast cells induced by a specific antigen. The histamine release induced by several substances such as concanavalin A, compound 48/80, mastoparan, and ionophore A23187, was also found to be inhibited by Pe-OP. These results suggest that Pe-GP mainly interrupts a pathway of histamine release after calcium influx. Anti-allergic activity of Pe-GP was investigated by ear-swelling response in mice that had been passively sensitized with IgE via intravenous injection. Pe-GP, injected intraperitoneally before exposure to the antigen, was found to inhibit the allergic response in a dosedependent manner (5-100 mg/kg). Pe-GP shows promise as an anti-allergic substance for medical use as well as in health foods.\n シソ(Perilla frutescens B_<RITTON>)葉熱水抽出液から分離精製されたシソ糖ペプチド(Pe-GP,6kDa)の抗アレルギー活性を検討した。Pe-GPは,ラット腹腔内より単離してIgEで感作したマスト細胞において,特異抗原で刺激したときに誘発されるヒスタミン遊離反応を抑制した。同様にPe-GPはconcanavalin A,compound48/80,mastoparan,ionophore A23187などの誘発するヒスタミン遊離反応も抑制した。これらの結果からPe-GPはヒスタミン遊離機構のうちカルシウム動員以降の経路を主として抑えると考えられる。Pe-GPの生体内における抗アレルギー活性は,IgEを静注して受動感作したマウスの耳介浮腫反応により検討した。抗原塗布前にあらかじめ腹腔内に投与しておくと,Pe-GPは5-100mg/mlの範囲で濃度依存的に浮腫を抑制し抗アレルギー活性を示した。Pe-GPの抗アレルギー活性を有する医薬品としての開発が,健康食品と同様,期待される。","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"和漢医薬学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"rights: 本文データは和漢医薬学会の許諾に基づき複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10486121","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13406302","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takagi, Shinobu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakagomi, Kazuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sadakane, Yutaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanimura, Takenori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akiyama, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oka, Syuichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukumori, Yasunori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Terasawa, Katsutoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hatanaka, Yasumaru"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-15"}],"displaytype":"detail","filename":"20010603.pdf","filesize":[{"value":"929.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20010603.pdf","url":"https://toyama.repo.nii.ac.jp/record/2806/files/20010603.pdf"},"version_id":"6e6d5f8a-3111-49d8-a4c6-6777c7d49f1c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Glycopeptide from Perilla frutescens BRITTON","subitem_subject_scheme":"Other"},{"subitem_subject":"Anti-allergic activity","subitem_subject_scheme":"Other"},{"subitem_subject":"Histamine release inhibition from mast cells","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Anti-allergic activity of Glycopeptide isolated from Perilla frutescens BRITTON","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Anti-allergic activity of Glycopeptide isolated from Perilla frutescens BRITTON"}]},"item_type_id":"2","owner":"3","path":["469"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-24"},"publish_date":"2008-01-24","publish_status":"0","recid":"2806","relation_version_is_last":true,"title":["Anti-allergic activity of Glycopeptide isolated from Perilla frutescens BRITTON"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T13:53:39.966407+00:00"}