@article{oai:toyama.repo.nii.ac.jp:00002456,
 author = {Kurokawa, Masahiko and Shiraki, Kimiyasu},
 issue = {suppl.},
 journal = {和漢医薬学雑誌 = Journal of traditional medicines},
 month = {},
 note = {application/pdf, We summarized the flow of our research on the development of antiviral traditional medicines, which was a collaboration with the late Professor Tsuneo Namba. Even if traditional medicines and compounds purified from them have strong antiviral activity in vitro, we believe they are just inhibitors and not medicines if they have no therapeutic efficacy in vivo. Therefore our study is based on the confirmation of the oral therapeutic efficacy with traditional dosages in humans. We first screened the in vitro-antiviral activity of typically and easily available traditional medicines that are currently used for the treatment of various chronic diseases in China, India and Japan. Then we selected the extracts of traditional medicines with prophylactic and therapeutic antiviral activity in animal infection models. By verifying the antiviral activity of extracts in vivo, their new indications for the use of viral infection would be established. In consequence, the drinking of the extracts of traditional medicines like a daily tea or coffee may be used as prophylaxis and therapy for diseases caused by viral infection and improve the quality of life. Here, we describe how the antiviral extracts of traditional medicines and active compounds involved in them were explored and characterized, based on a view that antiviral activity should be active in vivo., Article},
 pages = {138--144},
 title = {New antiviral agents from traditional medicines(Chemical & Pharmacological study)},
 volume = {22},
 year = {2005}
}