{"created":"2023-07-25T09:04:25.449027+00:00","id":2259,"links":{},"metadata":{"_buckets":{"deposit":"111d23b2-d464-4228-9662-6391478f2a60"},"_deposit":{"created_by":3,"id":"2259","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2259"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00002259","sets":["439:440:441:442"]},"author_link":["6175","153940","153939","153942","153941","153937"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"869","bibliographicPageStart":"865","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"Neurologia medico-chirurgica : 神経外科"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We attempted to determine whether the plasma concentration of basic fibroblast growth factor (bFGF) was elevated in brain tumor patients. The plasma concentration of bFGF was measured in 55brain tumor patients and 17 normal subjects by enzyme immunoassay. Upper limit of plasma bFGF in the normal subjects was 1.6 pg/ml. Elevated plasma bFGF levels were observed in 28 patients including 13 of 17 glioma patients, eight of 19 benign tumor patients, and seven of 19 malignant tumor patients. Twelve of 14 malignant glioma patients had elevated plasma bFGF levels. There was a good correlation (r = 0.42, p < 0.05) between the elevated plasma bFGF level and the tumor volume. Further studies are needed to determine whether the plasma bFGF level is a clinically useful diagnostic and prognostic marker for patients with brain tumors.\n 脳腫瘍患者の血漿中にbasic fibroblast growth factor (bFGF)が上昇しているかどうか検討した。対象は55例の脳腫瘍患者で、17名の健康成人をコントロールとした。健康成人の血漿bFGF値の上限は1.6pg/mlであり、脳腫瘍患者でこの値を超えたのは28例(51%)であった。これらの内訳は、グリオーマ患者17例中13例、良性腫瘍19例中8例、悪性腫瘍19例中7例で、特に悪性グリオーマでは14例中12例と高頻度であった。これら脳腫瘍患者では血数bFGF値とMRIから計測した腫瘍体積とはよく相関した。以上、血槃bFGF値は脳腫瘍患者の過半数で上昇していたが、腫瘍マーカーとしての有用性を示すためにはさらに検討が必要と考えられた。","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"153942","nameIdentifierScheme":"WEKO"}],"names":[{"name":"栗本, 昌紀"}]}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本脳神経外科学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"rights: 本文データは日本脳神経外科学会の許諾に基づきCiNiiから複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00358613","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"4708105","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kurimoto, Masanori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Endo, Shunro"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Hirashima, Yutaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishijima, Michiharu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takaku, Akira"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-15"}],"displaytype":"detail","filename":"shinkeigeka96-865.pdf","filesize":[{"value":"487.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"shinkeigeka96-865.pdf","url":"https://toyama.repo.nii.ac.jp/record/2259/files/shinkeigeka96-865.pdf"},"version_id":"64f737aa-dbb1-42be-9a45-8ffa5164bfe7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"basic fibroblast growth factor","subitem_subject_scheme":"Other"},{"subitem_subject":"brain tumor","subitem_subject_scheme":"Other"},{"subitem_subject":"immunoassay","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor marker","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Elevated Plasma Basic Fibroblast Growth Factor in Brain Tumor Patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Elevated Plasma Basic Fibroblast Growth Factor in Brain Tumor Patients"}]},"item_type_id":"2","owner":"3","path":["442"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-31"},"publish_date":"2008-01-31","publish_status":"0","recid":"2259","relation_version_is_last":true,"title":["Elevated Plasma Basic Fibroblast Growth Factor in Brain Tumor Patients"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T13:54:29.379608+00:00"}