{"created":"2023-07-25T09:04:21.697351+00:00","id":2189,"links":{},"metadata":{"_buckets":{"deposit":"47c7915a-551b-48b5-861d-48ebaf1ab8c0"},"_deposit":{"created_by":3,"id":"2189","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2189"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00002189","sets":["439:440:441:442"]},"author_link":["132260","132258","5928","132259","132261"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"175","bibliographicPageStart":"173","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"和漢医薬学雑誌 = Journal of traditional medicines"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Atopic dermatitis (AD) is a chronic inflammatory skin disorder with pruritic and eczematous lesions. AD is characterized by the predominant infiltration of Th2-type cells in the acute phase of skin lesions. Thymus and activation-regulated chemokine (TARC), a member of the CC chemokine superfamily was identified as a selective chemoattractant for Th2-type cells. The serum TARC level is significantly increased in patients with AD and is correlated with the severity of AD. Keishibukuryogan (KBG) is a Kampo formula composed of five kind of crude drugs and has been administered to patients with blood stagnation in Japan. This study investigated the effect of KBG on disease activity and TARC production in AD patients. AD patients were administered KBG for 4 to 6 weeks in addition to their prescribed medications. The SCORAD index and VAS score were decreased by the administration of KBG. The serum TARC level of the AD patients was much higher than that of normal controls. This elevated serum TARC level was significantly decreased by administration of KBG. These results suggest that KBG may improve AD by the inhibitory effect on Th2-type chemokine production.\n アトピー性皮膚炎は痒みと湿疹病変を伴う慢性炎症性疾患であり,その急性期には皮膚病変内に多くのTh2細胞の浸潤がみられる。TARCはCCケモカインのひとつで,このTh2細胞に対して選択的な遊走活性を持つ。また,アトピー性皮膚炎患者では血清TARC値が正常と比較し有意に上昇しており,さらに重症度と相関することが知られている。一方,駆瘀血剤のひとつである桂枝茯苓丸は,これまで主に血栓症や動脈硬化症の患者の治療に用いられてきた。今回我々はアトピー性皮膚炎患者における疾患活動性とTARC産生に対する桂枝茯苓丸の作用について検討した。36名のアトピー性皮膚炎患者に4～6週間桂枝茯苓丸を投与し,投与前後でSCORAD index,VAS scoreを計測しその効果を評価した。また同時に血清TARC値も測定した。その結果,桂枝茯苓丸内服前に高値であったSCORAD index,VAS scoreは,内服後には有意に低下していた。また血清TARC値も投与前は高値であったが,内服後は有意に低下していた。以上の結果より,桂枝茯苓丸はこれまで知られていた作用に加えTARC産生を抑制する可能性が示唆され,アトピー性皮膚炎などTh2ケモカインが関与する炎症性疾患に対して有用な治療法になりうることが期待された。","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"和漢医薬学会"}]},"item_2_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"rights: 本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12035198","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"18801447","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Makino, Teruhiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Furuichi, Megumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Hirokazu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshihisa, Yoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimizu, Tadamichi"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-15"}],"displaytype":"detail","filename":"JtrMed07-makino.pdf","filesize":[{"value":"292.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JtrMed07-makino.pdf","url":"https://toyama.repo.nii.ac.jp/record/2189/files/JtrMed07-makino.pdf"},"version_id":"18c8c47f-dba2-4065-bb98-57c920be1b64"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Atopic dermatitis","subitem_subject_scheme":"Other"},{"subitem_subject":"Thymus and activation-regulated chemokine (TARC)","subitem_subject_scheme":"Other"},{"subitem_subject":"Keishibukuryogan","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Keishibukuryogan (Gui-Zhi-Fu-Ling-Wan), a Kampo formula decreases the disease activity and the level of serum thymus and activation-regulated chemokine (TARC) in patients with atopic dermatitis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Keishibukuryogan (Gui-Zhi-Fu-Ling-Wan), a Kampo formula decreases the disease activity and the level of serum thymus and activation-regulated chemokine (TARC) in patients with atopic dermatitis"}]},"item_type_id":"2","owner":"3","path":["442"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-12-26"},"publish_date":"2007-12-26","publish_status":"0","recid":"2189","relation_version_is_last":true,"title":["Keishibukuryogan (Gui-Zhi-Fu-Ling-Wan), a Kampo formula decreases the disease activity and the level of serum thymus and activation-regulated chemokine (TARC) in patients with atopic dermatitis"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T13:03:08.880947+00:00"}