{"created":"2023-07-25T09:19:00.127261+00:00","id":19952,"links":{},"metadata":{"_buckets":{"deposit":"48fe9ae1-d6b4-449f-b4f8-4204d70f4710"},"_deposit":{"created_by":3,"id":"19952","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"19952"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00019952","sets":["439:440:443:1496:2125"]},"author_link":["182609","182613","182614","182610","182611","182612"],"item_3_alternative_title_19":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Sleep state-specific neuronal activity dynamics in the prefrontal cortex"}]},"item_3_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"41","bibliographicPageStart":"31","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"Toyama medical journal"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"内側前頭前野は多数の脳領域からの情報を統合しており，その機能の実現のために睡眠中の働きが注目されている。睡眠はrapid eye movement（REM）睡眠とnon-REM（NREM）睡眠に分けられ，それぞれが異なる様式で，様々な脳機能に貢献すると考えられているが，その神経基盤は不明である。我々は睡眠中のマウスの内側前頭前野をカルシウムイメージング法によって撮影し，各睡眠状態に特徴的な神経活動を解析した。その結果，NREMとREM睡眠中の神経活動特性は有意に異なり，その差異は睡眠状態の切り替わりに鋭敏に反応する細胞集団によって構成されていることが明らかになった。内側前頭前野のNREMまたはREM特異的な活動特性は長期間保存されるため，これらは回路として組み込まれた機能である可能性が高い。以上の結果は，NREMとREM睡眠の機能的役割の違いが，回路レベルで実現されていることを示唆している。\n\\nThe medial prefrontal cortex integrates information from numerous brain regions, and its function during sleep has become of interest. Sleep can be divided into rapid eye movement (REM) and non-REM (NREM) sleep, each of which is thought to play distinct roles in various brain functions, but its neural basis is unknown. We recorded the cell activities in medial prefrontal cortex of sleeping mice using calcium imaging and analyzed the neuronal activity characteristic of each sleep state. The\nresults revealed that the characteristics of neural activity during NREM and REM sleep differ significantly and that the differences are attributed to cell populations that acutely response to the sleep state switching. NREM or REM-specific activity properties in the medial prefrontal cortex are likely to reflect hard-wired functions, as these were preserved over time. We demonstrate that the hard-wired circuits contribute to the distinct functional roles of NREM and REM sleep.","subitem_description_type":"Abstract"}]},"item_3_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_3_description_6":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Toyama medical journal, 33(1), 2023.3, pp.51-55","subitem_description_type":"Other"}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"182612","nameIdentifierScheme":"WEKO"}],"names":[{"name":"OHNO, Shuntaro"}]},{"nameIdentifiers":[{"nameIdentifier":"182613","nameIdentifierScheme":"WEKO"}],"names":[{"name":"OMOTO, Masanori"}]},{"nameIdentifiers":[{"nameIdentifier":"182614","nameIdentifierScheme":"WEKO"}],"names":[{"name":"INOKUCHI, Kaoru"}]}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"富山大学医学会"}]},"item_3_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.57561/tmjutmed.33.1_43","subitem_relation_type_select":"DOI"}}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12720250","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21892467","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大野, 駿太郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"野本, 真順"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"井ノ口, 馨"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-04-14"}],"displaytype":"detail","filename":"TMJ033_043to049.pdf","filesize":[{"value":"11.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"TMJ033_043to049.pdf","url":"https://toyama.repo.nii.ac.jp/record/19952/files/TMJ033_043to049.pdf"},"version_id":"4f56a3e2-d4cb-4791-b64f-a7525a818dd4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Sleep","subitem_subject_scheme":"Other"},{"subitem_subject":"Prefrontal cortex","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcium imaging","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"睡眠状態に特異的な前頭前野の神経活動動態","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"睡眠状態に特異的な前頭前野の神経活動動態"}]},"item_type_id":"3","owner":"3","path":["2125"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-04-14"},"publish_date":"2023-04-14","publish_status":"0","recid":"19952","relation_version_is_last":true,"title":["睡眠状態に特異的な前頭前野の神経活動動態"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T10:33:25.319761+00:00"}