{"created":"2023-07-25T09:15:47.038753+00:00","id":15779,"links":{},"metadata":{"_buckets":{"deposit":"31e1a8f6-48e8-4ec5-975c-96e697afaf1b"},"_deposit":{"created_by":19,"id":"15779","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"15779"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00015779","sets":["496:556:557:558"]},"author_link":["38014","30046","37156","167954","167955"],"item_2_alternative_title_19":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Discovery of novel adenylyl cyclase inhibitor by cell-based screening."}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"1693","bibliographicPageStart":"1689","bibliographicVolumeNumber":"37","bibliographic_titles":[{"bibliographic_title":"Biological & pharmaceutical bulletin"},{"bibliographic_title":"Biological & pharmaceutical bulletin"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We screened 2400 compounds to find novel inhibitors of the adenylyl cyclase (AC)-protein kinase A (PKA)-cAMP response-element-binding protein (CREB) signaling pathway (AC/PKA/CREB pathway). Using a multistep cell-based screening system employing split luciferase technique, we narrowed down the candidates effectively from 2400 chemical compounds and identified a novel AC inhibitor (compound 1). Since dysregulation of the AC/PKA/CREB pathway is known to cause diseases not only in the nervous system but also in other organs, compound 1 is expected to be developed as a medicine for these diseases.","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Biological & pharmaceutical bulletin 37(10), 1689-1693.(2014)","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"THE PHARMACEUTICAL SOCIETY OF JAPAN"},{"subitem_publisher":"公益社団法人日本薬学会"}]},"item_2_relation_11":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"25273392","subitem_relation_type_select":"PMID"}}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-5215","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mano, Hiroki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ishimoto, Tetsuya"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Okada, Takuya"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Toyooka, Naoki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Mori, Hisashi"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-02"}],"displaytype":"detail","filename":"BiolPharmBull_37_10_1689to1693_Toyooka.pdf","filesize":[{"value":"587.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BiolPharmBull_37_10_1689to1693_Toyooka","url":"https://toyama.repo.nii.ac.jp/record/15779/files/BiolPharmBull_37_10_1689to1693_Toyooka.pdf"},"version_id":"3085eaef-33f2-4932-8b73-8db51ee3297c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adenylyl Cyclase Inhibitors","subitem_subject_scheme":"Other"},{"subitem_subject":"Adenylyl Cyclases","subitem_subject_scheme":"Other"},{"subitem_subject":"Dose-Response Relationship, Drug","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug Discovery","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug Evaluation, Preclinical","subitem_subject_scheme":"Other"},{"subitem_subject":"Enzyme Inhibitors","subitem_subject_scheme":"Other"},{"subitem_subject":"HEK293 Cells","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_scheme":"Other"},{"subitem_subject":"Adenylyl Cyclase Inhibitors","subitem_subject_scheme":"Other"},{"subitem_subject":"Adenylyl Cyclases","subitem_subject_scheme":"Other"},{"subitem_subject":"Dose-Response Relationship, Drug","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug Discovery","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug Evaluation, Preclinical","subitem_subject_scheme":"Other"},{"subitem_subject":"Enzyme Inhibitors","subitem_subject_scheme":"Other"},{"subitem_subject":"HEK293 Cells","subitem_subject_scheme":"Other"},{"subitem_subject":"Humans","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Discovery of novel adenylyl cyclase inhibitor by cell-based screening.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Discovery of novel adenylyl cyclase inhibitor by cell-based screening."},{"subitem_title":"Discovery of novel adenylyl cyclase inhibitor by cell-based screening.","subitem_title_language":"en"}]},"item_type_id":"2","owner":"19","path":["558"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-03-02"},"publish_date":"2018-03-02","publish_status":"0","recid":"15779","relation_version_is_last":true,"title":["Discovery of novel adenylyl cyclase inhibitor by cell-based screening."],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2023-07-25T14:23:16.543036+00:00"}