@article{oai:toyama.repo.nii.ac.jp:00015779,
 author = {Mano, Hiroki and Ishimoto, Tetsuya and Okada, Takuya and Toyooka, Naoki and Mori, Hisashi},
 issue = {10},
 journal = {Biological & pharmaceutical bulletin, Biological & pharmaceutical bulletin},
 month = {Mar},
 note = {application/pdf, We screened 2400 compounds to find novel inhibitors of the adenylyl cyclase (AC)-protein kinase A (PKA)-cAMP response-element-binding protein (CREB) signaling pathway (AC/PKA/CREB pathway). Using a multistep cell-based screening system employing split luciferase technique, we narrowed down the candidates effectively from 2400 chemical compounds and identified a novel AC inhibitor (compound 1). Since dysregulation of the AC/PKA/CREB pathway is known to cause diseases not only in the nervous system but also in other organs, compound 1 is expected to be developed as a medicine for these diseases., Article, Biological & pharmaceutical bulletin 37(10), 1689-1693.(2014)},
 pages = {1689--1693},
 title = {Discovery of novel adenylyl cyclase inhibitor by cell-based screening.},
 volume = {37},
 year = {2014}
}