{"created":"2023-07-25T09:15:46.604994+00:00","id":15769,"links":{},"metadata":{"_buckets":{"deposit":"2124cd5a-c00b-4291-bf62-e48278bf4689"},"_deposit":{"created_by":19,"id":"15769","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"15769"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00015769","sets":["496:556:557:558"]},"author_link":["30046"],"item_2_alternative_title_19":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Synthesis and Its Application to the Synthesis of Biologically Active Natural Products of New and Versatile Chiral Building Blocks"}]},"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-07-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"479","bibliographicPageStart":"467","bibliographicVolumeNumber":"121","bibliographic_titles":[{"bibliographic_title":"藥學雜誌 = Journal of the Pharmaceutical Society of Japan"},{"bibliographic_title":"YAKUGAKU ZASSHI"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This article describes a design and synthesis of new and versatile chiral building blocks and its application to the biologically active natural product synthesis. The chiral building blocks were prepared using a biocatalysis in an enantiomerically pure state. As an application of the above chiral building blocks to the synthesis of biologically active natural product, we demonstrated the diastereodivergent synthesis of the 3-piperidinol alkaloids cassine, spectaline, prosafrinine, iso-6-cassine, prosophylline, prosopinine, and also established the flexible route to the 5,8-disubstituted indolizidine or 1,4-disubstituted quinolizidine type of Dendrobates alkaloids. As another application to the synthesis of biologically active alkaloids, we accomplished the first enantioselective total synthesis of marine alkaloids clavepictines A, B, and pictamine using a highly stereoselective Michael type quinolizidine ring closure reaction as the crucial step, and the first total synthesis of a marine alkaloid lepadin B was also achieved using aldol cyclization controlled by a A<SUP>(1,3)</SUP> strain.","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本総説は，平成12年度日本薬学会北陸支部学術奨励賞の受賞を記念して記述したものである．","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"藥學雜誌 = Journal of the Pharmaceutical Society of Japan 12(7), 467-479.(2001)","subitem_description_type":"Other"}]},"item_2_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"30046","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000010217565","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000010217565"},{"nameIdentifier":"10217565","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000010217565"}],"names":[{"name":"Toyooka, Naoki"}]}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"公益社団法人日本薬学会"},{"subitem_publisher":"THE PHARMACEUTICAL SOCIETY OF JAPAN"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/yakushi.121.467","subitem_relation_type_select":"DOI"}}]},"item_2_relation_29":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110003648535","subitem_relation_type_select":"NAID"}}]},"item_2_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00284903","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00316903","subitem_source_identifier_type":"ISSN"}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"豊岡, 尚樹"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-01"}],"displaytype":"detail","filename":"YakugakuZasshi_121_7_467to479_Toyooka.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"YakugakuZasshi_121_7_467to479_Toyooka","url":"https://toyama.repo.nii.ac.jp/record/15769/files/YakugakuZasshi_121_7_467to479_Toyooka.pdf"},"version_id":"11def233-8f56-43c7-b571-4295496dbc73"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"chiral building blocks","subitem_subject_scheme":"Other"},{"subitem_subject":"Dendrobates alkaloids","subitem_subject_scheme":"Other"},{"subitem_subject":"clavepictines","subitem_subject_scheme":"Other"},{"subitem_subject":"pictamine","subitem_subject_scheme":"Other"},{"subitem_subject":"lepadin B, A(1,3) strain","subitem_subject_scheme":"Other"},{"subitem_subject":"chiral building blocks","subitem_subject_scheme":"Other"},{"subitem_subject":"Dendrobates alkaloids","subitem_subject_scheme":"Other"},{"subitem_subject":"clavepictines","subitem_subject_scheme":"Other"},{"subitem_subject":"pictamine","subitem_subject_scheme":"Other"},{"subitem_subject":"lepadin B, A(1,3) strain","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"新規汎用性キラル素子の創製とその生物活性天然物合成への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規汎用性キラル素子の創製とその生物活性天然物合成への応用"},{"subitem_title":"Synthesis and Its Application to the Synthesis of Biologically Active Natural Products of New and Versatile Chiral Building Blocks","subitem_title_language":"en"}]},"item_type_id":"2","owner":"19","path":["558"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-03-01"},"publish_date":"2018-03-01","publish_status":"0","recid":"15769","relation_version_is_last":true,"title":["新規汎用性キラル素子の創製とその生物活性天然物合成への応用"],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2023-07-25T14:23:29.384266+00:00"}