{"created":"2023-07-25T09:15:45.875097+00:00","id":15752,"links":{},"metadata":{"_buckets":{"deposit":"be00184e-83f7-402a-b6f4-2c54dd1c0934"},"_deposit":{"created_by":17,"id":"15752","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"15752"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00015752","sets":["646:647:648"]},"author_link":["167894","167889","167892","167888","6558","47801","6184","167887","167890"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Cancer Immunology Research"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although NK cells are recognized as direct antitumor effectors, the ability of NK cells to control cancer-associated inflammation, which facilitates tumor progression, remains unknown. In this study, we demonstrate that NK cells control tumor-promoting inflammation through functional modification of neutrophils. NK cells control the tumor-promoting function of neutrophils through an IFNgamma-dependent mechanism. Tumor progression in an NK cell-depleted host is diminished when the IL17A-neutrophil axis is absent. In NK cell-depleted mice, neutrophils acquire a tumor-promoting phenotype, characterized by up-regulation of VEGF-A expression, which promotes tumor growth and angiogenesis. A VEGFR inhibitor which preferentially suppressed tumor growth in NK cell-depleted mice was dependent on neutrophils. Furthermore, the systemic neutropenia caused by an anti-metabolite treatment showed an anti-cancer effect only in mice lacking NK cells. Thus, NK cells likely control the tumor-promoting and angiogenic function of neutrophils.","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"Cancer Immunology Research , DOI: 10.1158/2326-6066.CIR-17-0204 ","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Association for Cancer Research Pubblications"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1158/2326-6066.CIR-17-0204 ","subitem_relation_type_select":"DOI"}}]},"item_2_relation_42":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"出版社版"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1158/2326-6066","subitem_relation_type_select":"DOI"}}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ogura, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato-Matsushita, Marimo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Seiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hori, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasahara, Masakiyo"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Iwakura, Yoichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saiki, Ikuo"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Tahara, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayakawa, Yoshihiro"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-01-23"}],"displaytype":"detail","filename":"CIR_Hayakawa.pdf","filesize":[{"value":"4.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CIR_Hayakawa","url":"https://toyama.repo.nii.ac.jp/record/15752/files/CIR_Hayakawa.pdf"},"version_id":"f1685ea3-c95c-4bb8-97cc-16b9817c4eee"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"NK cells control tumor-promoting function of neutrophils in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"NK cells control tumor-promoting function of neutrophils in mice"}]},"item_type_id":"2","owner":"17","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-01-23"},"publish_date":"2019-01-23","publish_status":"0","recid":"15752","relation_version_is_last":true,"title":["NK cells control tumor-promoting function of neutrophils in mice"],"weko_creator_id":"17","weko_shared_id":17},"updated":"2023-11-06T04:44:34.375356+00:00"}