{"created":"2023-07-25T09:15:42.666211+00:00","id":15675,"links":{},"metadata":{"_buckets":{"deposit":"8490ebbe-dba1-4d6c-89b9-b455b043839c"},"_deposit":{"created_by":17,"id":"15675","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"15675"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00015675","sets":["646:647:648"]},"author_link":["167721","6558","47801","167722","167723"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"PLoS ONE"}]}]},"item_2_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Kampo formulations comprise a number of crude natural drugs/herbs as constituents. The crude drugs/herbs have been traditionally classified by their traditional classifications or efficacies in Kampo medicines; however, it has been difficult to establish the scientific link between experimental evidence and traditional classifications in Kampo medicine. To clarify such traditional conceptions, we tested 112 crude drugs/herbs that are major components of Kampo formulations, in the multi-pathway analysis of 10 well-studied transcriptional activities including CREB, ERSF, HIF-1α, IRFs, MYC, NF-κB, p53, SMAD, SOX2, and TCF/LEF in A549 human lung cancer cells. By clustering the results of multi-pathway analysis with the Spearman rank-correlation coefficient and Ward linkage, three distinct traditional categories were significantly enriched in the major groupings, which are heat-clearing and dampness-drying herbs, acrid and warm exterior-resolving herbs, and acrid and cool exterior-resolving herbs. These results indicate that these crude drugs/herbs have similar effects on intracellular signaling and further imply that the traditional classifications of those enriched crude drugs/herbs can be supported by such experimental evidence. Collectively, our new in vitro multi-pathway analysis may be useful to clarify the mechanism of action of crude drugs/herbs and Kampo formulations.","subitem_description_type":"Abstract"}]},"item_2_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"PLoS ONE, 2015 Jun 2; 10(6): e0128872","subitem_description_type":"Other"}]},"item_2_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Public Library of Science"}]},"item_2_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1371/journal.pone.128872","subitem_relation_type_select":"DOI"}}]},"item_2_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Eshima, Shizuka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yokoyama, Satoru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abe, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayakawa, Yoshihiro"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Saiki, Ikuo"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-02-08"}],"displaytype":"detail","filename":"PLoSONE_10(6)_e0128872_Eshima.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"label":"PLoSONE_10(6)_e0128872_Eshima","url":"https://toyama.repo.nii.ac.jp/record/15675/files/PLoSONE_10(6)_e0128872_Eshima.pdf"},"version_id":"46782528-de56-408d-bbcd-58c1506d5e4e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Multi-pathway cellular analysis on crude natural drugs/herbs from Japanese Kampo formulations","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Multi-pathway cellular analysis on crude natural drugs/herbs from Japanese Kampo formulations"}]},"item_type_id":"2","owner":"17","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-08"},"publish_date":"2018-02-08","publish_status":"0","recid":"15675","relation_version_is_last":true,"title":["Multi-pathway cellular analysis on crude natural drugs/herbs from Japanese Kampo formulations"],"weko_creator_id":"17","weko_shared_id":17},"updated":"2023-11-06T04:44:36.713960+00:00"}