{"created":"2023-07-25T09:14:40.080069+00:00","id":14385,"links":{},"metadata":{"_buckets":{"deposit":"3fb548cf-6482-4415-a2b3-f29925061956"},"_deposit":{"created_by":22,"id":"14385","owners":[22],"pid":{"revision_id":0,"type":"depid","value":"14385"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00014385","sets":["663:664:667:668:1598"]},"author_link":["36314"],"item_3_alternative_title_19":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Analysis of Molecular Weight Forms of Adiponectin in Type 2"}]},"item_3_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"13","bibliographicPageStart":"9","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"学園の臨床研究"}]}]},"item_3_description_15":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アディポネクチンは脂肪細胞から分泌されるサイトカインであり、インスリンの感受性の亢進、抗動脈硬化作用を有することが知られている。又、アディポネクチン(Ad)は、三つのisoforms（高分子量）(High molecular weight;HMW)中分子量(middle molecular weight;MMW)低分子量(low molecular weight;LMW))の形で血液中に存在し、これらの総和である、総アディポネクチン(Total-Ad)、高分子量アディポネクチン(HMW-Ad)が2型糖尿病(T2D)で低下する事や、インスリン抵抗性(IR)減弱と関連する事はよく知られている。しかし、T2Dと、HMW-Ad以外の中分子量Ad(MMW-Ad)、低分子量Ad(LMW-Ad)との関連についてはあまり検討されていない。その為、今回、アディポネクチン(Ad)三分画と2型糖尿病(T2D)、インスリン抵抗性(IR)との関連について、富山大学附属病院第一内科もしくは、その関連施設に通院中のT2D394名、非T2D(CO)374名において検討した。\n尚、Total(T)-Ad、Ad三分画(HMW-Ad,MMW-Ad,LMW-Ad)の絶対値だけでなく、各Ad三分画のT-Adの比(HMW/T,MMW/T,LMW/T)についても検討した。その結果、T2DでT-Ad及びすべてのAd三分画は、交絡因子で調整後も有意に低値であった。比についてはT2Dで有意にHMW/Tは高値であった。T-Ad及び全てのAd三分画は、インスリン抵抗性の指標であるHOMA-IRと交絡因子で調整後も負の相関を認め、比については、HOMA-IRは、HMW/Tと負の相関、LMW/Tとは正の相関を認めた。今回、HMW-Aｄ以外のAd分画であるLMW-Adの割合がT2Dで増加する事や、インスリン抵抗性と関連することを明らかにした。","subitem_description_type":"Abstract"}]},"item_3_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_3_description_6":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"学園の臨床研究, No.16, Page 9-13","subitem_description_type":"Other"}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"36314","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"9000006008232","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/9000006008232"},{"nameIdentifier":"20345565","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000020345565"}],"names":[{"name":"Iwata, Minoru"}]}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15099/00016873","subitem_identifier_reg_type":"JaLC"}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"富山大学保健管理センター"}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11893140","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_8":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13464213","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岩田, 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MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ClinicalStudyOfCampusLife_16_01-03_Page009-013","url":"https://toyama.repo.nii.ac.jp/record/14385/files/ClinicalStudyOfCampusLife_16_01-03_Page009-013.pdf"},"version_id":"c66fa276-fb88-4e59-a75a-830ebe2941a8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"2型糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"T2D","subitem_subject_scheme":"Other"},{"subitem_subject":"アディポネクチン","subitem_subject_scheme":"Other"},{"subitem_subject":"Ad","subitem_subject_scheme":"Other"},{"subitem_subject":"三分画","subitem_subject_scheme":"Other"},{"subitem_subject":"インスリン抵抗性","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin 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