{"created":"2023-07-25T09:13:57.091498+00:00","id":13399,"links":{},"metadata":{"_buckets":{"deposit":"4b7bfcb2-17e8-44b7-8edd-c4f32b8cd007"},"_deposit":{"created_by":3,"id":"13399","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13399"},"status":"published"},"_oai":{"id":"oai:toyama.repo.nii.ac.jp:00013399","sets":["646:649:650:1539"]},"author_link":["161104","161103","161105","161106"],"item_3_alternative_title_19":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Aldose Reductase Inhibitory Activity of Chinese Crude Drug \"Danshen\""}]},"item_3_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-04-28","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"15","bibliographicPageStart":"1","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"和漢薬研究所年報　=　Annual Report Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University"}]}]},"item_3_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"漢薬“丹参”の基源植物である丹参（Salvia miltiorhiza）及び中国新彊において丹参（S.miltiorhiza）の代用品として用いられている新彊丹参（S.deserta）のアルドース還元酵素阻害活性成分を調べたところ，両者の活性成分は全く異なっていた。さらに，丹参（S.miltiorhiza）の代用品として用いられている10種を含む17種類のSalvia属植物について，水およびメタノールエキスのアルドース還元酵素阻害活性およびLC-MS分析を比較した結果も，それらSalvia属植物が同等ではない事を示していた。これらの結果から，丹参（S.miltiorhiza）の代用品として他のSalvia属植物を用いる場合には，作用や成分に関する考慮を払った上で用いる必要があると考えられた。さらに，このような同属植物聞の成分比較にLC-MS分析と主成分分析の組み合わせが有用な手法となると思われた。","subitem_description_type":"Abstract"},{"subitem_description":"We examined the aldose reductase (AR) inhibitory constituents of Salvia miltiorhiza，the original plant of Chinese crude drug Danshen, and S.deserta，a plant mixed in Danshen at Xinjiang province, China in short supply of S.miltiorhiza，and found that their AR inhibitory constituents differed very much. Then, we also examined the AR inhibitory activity and liquid chromatography mass spectrometry (LC-MS) of water and MeOH extracts of seventeen Salvia plants, including ten species used as Danshen resources and indicated that the seventeen plants were not the same as S.miltiorhiza. Thus, it has been concluded that on usage of other Salvia plant(s) instead of S.miltiorhiza their activity and/or constituents should be considered. Moreover, these results have also suggested that for the comparison of the plants of the same genus a combination of LC-MS and principle component analysis would be useful method.","subitem_description_type":"Abstract"}]},"item_3_description_40":{"attribute_name":"資源タイプ(DSpace)","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_3_description_6":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"和漢薬研究所年報, 第26巻, 2000.04.28, Page 1-15","subitem_description_type":"Other"}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"161105","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kadota, Shigetoshi"}]},{"nameIdentifiers":[{"nameIdentifier":"161106","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tezuka, Yasuhiro"}]}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15099/00015904","subitem_identifier_reg_type":"JaLC"}]},"item_3_publisher_33":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"富山医科薬科大学和漢薬研究所"}]},"item_3_relation_29":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110000369802","subitem_relation_type_select":"NAID"}}]},"item_3_source_id_10":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00258062","subitem_source_identifier_type":"NCID"}]},"item_3_subject_17":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.3","subitem_subject_scheme":"NDC"}]},"item_3_version_type_16":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"門田, 重利"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"手塚, 康弘"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-08-12"}],"displaytype":"detail","filename":"INMTMPU_Annualreport_26_01-01_Page001to015.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"INMTMPU_Annualreport_26_01-01_Page001to015.pdf","url":"https://toyama.repo.nii.ac.jp/record/13399/files/INMTMPU_Annualreport_26_01-01_Page001to015.pdf"},"version_id":"7ed01af8-a3e0-4952-ac1f-5496e7844986"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Salvia","subitem_subject_scheme":"Other"},{"subitem_subject":"liquid chromatography-mass spectrometry (LC-MS)","subitem_subject_scheme":"Other"},{"subitem_subject":"aldose reductase inhibitor","subitem_subject_scheme":"Other"},{"subitem_subject":"principle component analysis","subitem_subject_scheme":"Other"},{"subitem_subject":"丹参（Danshen)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"漢薬\"丹参\"のアルドース還元酵素阻害活性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"漢薬\"丹参\"のアルドース還元酵素阻害活性"}]},"item_type_id":"3","owner":"3","path":["1539"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-12"},"publish_date":"2016-08-12","publish_status":"0","recid":"13399","relation_version_is_last":true,"title":["漢薬\"丹参\"のアルドース還元酵素阻害活性"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-25T15:49:35.276331+00:00"}